Gamma-band synchronization in visual cortex predicts speed of change detection

被引:566
作者
Womelsdorf, T [1 ]
Fries, P
Mitra, PP
Desimone, R
机构
[1] Radboud Univ, FC Donders Ctr Cognit Neuroimaging, NL-6525 EN Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Dept Biophys, NL-6525 EZ Nijmegen, Netherlands
[3] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[4] NIMH, Neuropsychol Lab, NIH, Bethesda, MD 20892 USA
[5] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA
关键词
D O I
10.1038/nature04258
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Our capacity to process and respond behaviourally to multiple incoming stimuli is very limited. To optimize the use of this limited capacity, attentional mechanisms give priority to behaviourally relevant stimuli at the expense of irrelevant distractors. In visual areas, attended stimuli induce enhanced responses and an improved synchronization of rhythmic neuronal activity in the gamma frequency band (40 - 70 Hz)(1-11). Both effects probably improve the neuronal signalling of attended stimuli within and among brain areas(1,12-16). Attention also results in improved behavioural performance and shortened reaction times. However, it is not known how reaction times are related to either response strength or gamma-band synchronization in visual areas. Here we show that behavioural response times to a stimulus change can be predicted specifically by the degree of gamma-band synchronization among those neurons in monkey visual area V4 that are activated by the behaviourally relevant stimulus. When there are two visual stimuli and monkeys have to detect a change in one stimulus while ignoring the other, their reactions are fastest when the relevant stimulus induces strong gamma-band synchronization before and after the change in stimulus. This enhanced gamma-band synchronization is also followed by shorter neuronal response latencies on the fast trials. Conversely, the monkeys' reactions are slowest when gamma-band synchronization is high in response to the irrelevant distractor. Thus, enhanced neuronal gamma-band synchronization and shortened neuronal response latencies to an attended stimulus seem to have direct effects on visually triggered behaviour, reflecting an early neuronal correlate of efficient visuo-motor integration.
引用
收藏
页码:733 / 736
页数:4
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