What is General Philosophy of Science?

The very idea of a general philosophy of science relies on the assumption that there is this thing called science-as opposed to the various individual sciences. In this programmatic piece I make a case for the claim that general philosophy of science is the philosophy of science in general or science as such. Part of my narrative makes use of history, for two reasons. First, general philosophy of science is itself characterised by an intellectual tradition which aimed to develop a coherent philosophical view of science, qua a part of culture with distinctive epistemic features and a distinctive relation to reality. But, second, this tradition went through some important conceptual shifts which re-oriented it and made it more sensitive to the actual development of science itself. The historical narrative focuses on three such moments: the defining moment, associated with Aristotle, and two major conceptual turns, related to Kant and Duhem. The pressures on the very idea of a general philosophy of science that followed the collapse of the macro-models of science that became popular in the 1960s, the pressures that lay all of the emphasis on fragmentation and not on integration, can be dealt with by a new synthesis within general philosophy of science of the constitutive and the historical, in light of the intellectual tradition that has defined it.