NMR spectroscopy of G-quadruplexes

被引：239

作者：

Adrian, Michael ^{[1
]}

Heddi, Brahim ^{[1
]}

Anh Tuan Phan ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Phys & Appl Phys, Singapore, Singapore

来源：

METHODS | 2012年 / 57卷 / 01期

关键词：

DNA; G-quadruplex; NMR; RNA; HUMAN TELOMERIC DNA; DIMERIC G-QUADRUPLEX; 5'-GUANOSINE MONOPHOSPHATE DIANION; MAGNETIC-RELAXATION DISPERSION; INTRAMOLECULAR G-QUADRUPLEX; THROUGH-BOND CORRELATION; AMMONIUM ION MOVEMENT; RNA G-QUADRUPLEXES; NOVA G-QUADRUPLEX; N HYDROGEN-BONDS;

D O I：

10.1016/j.ymeth.2012.05.003

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

G-rich DNA and RNA sequences can form four-stranded structures called G-quadruplexes. Such structures have gained significant interest in the past decade with increasing evidence of their biological role. G-quadruplex structures can be polymorphic and dynamic. NMR spectroscopy has played an important role in G-quadruplex research. Here we review on the application of NMR techniques to study structure, dynamics and interaction of G-quadruplexes. (C) 2012 Published by Elsevier Inc.

引用

页码：11 / 24

页数：14

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