Steroidal saponins from Paris polyphylla var. yunnanensis

被引：60

作者：

Wu, Xia ^{[1
,2
]}

Wang, Lei ^{[1
,2
]}

Wang, Hui ^{[3
]}

Dai, Yi ^{[1
,2
]}

Ye, Wen-Cai ^{[1
,2
]}

Li, Yao-Lan ^{[1
,2
]}

机构：

[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[3] Jinan Univ, Sch Med, Guangzhou 510632, Guangdong, Peoples R China

来源：

PHYTOCHEMISTRY | 2012年 / 81卷

基金：

中国国家自然科学基金;

关键词：

Paris polyphylla var. yunnanensis; Liliaceae; Steroidal saponins; Cytotoxic effect; CNE cells; CYTOTOXIC ACTIVITY; IN-VITRO; CONSTITUENTS; RHIZOMES; GROWTH;

D O I：

10.1016/j.phytochem.2012.05.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eleven steroidal saponins, along with seven known steroidal saponins, were isolated from rhizomes of Paris polyphylla var. yunnanensis. Their chemical structures were elucidated on the basis of spectroscopic analyses and acid hydrolysis. Two of these compounds contained a spirostanol saponin aglycone, hitherto unknown in Nature. The isolated compounds were tested for their cytotoxic effects on human nasopharyngeal carcinoma epithelial (CNE) cells, and seven compounds displayed more potent inhibitory effects than cisplatin (the positive control). One compound with diosgenin and tetrasaccharide moieties possessed the strongest inhibitory effect on CNE cells through the induction of apoptosis and cell cycle arrest. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：133 / 143

页数：11

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