Preliminary evidence that pharmacologic melatonin treatment decreases rat ghrelin levels

被引：48
作者：
Mustonen, AM [1 ]
Nieminen, P [1 ]
Hyvärinen, H [1 ]
机构：
[1] Univ Joensuu, Dept Biol, FIN-80101 Joensuu, Finland
来源：
ENDOCRINE | 2001年 / 16卷 / 01期
基金：
芬兰科学院;
关键词：
ghrelin; growth hormone; leptin; rnelatonin; rat;
D O I：
10.1385/ENDO:16:1:43
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ghrelin is a signal peptide isolated from rat stomach antagonistic to actions of leptin. Ghrelin stimulates the secretion of growth hormone (GH) and increases food intake, body mass, and adiposity in rodents. Photoperiod and melatonin regulate leptin secretion of mammals. The aim of the study was to investigate possible melatonin-ghrelin interactions in weight regulation by studying the effects of continuous pharmacologic melatonin treatment and constant light on plasma ghrelin, leptin, and GH levels in rats. Plasma ghrelin concentrations were significantly reduced by exogenous melatonin. Ghrelin levels correlated negatively with plasma leptin levels in control rats kept in 12 h of light/ 12 h of dark but not in the melatonin-treated animals. The inverse ghrelin-leptin relationship was also disrupted by constant illumination. The circulating ghrelin and! GH levels may not be interrelated in all metabolic situations. The results suggest new interplay between the pineal gland and energy metabolism as well as reenforce the hypothesis that ghrelin is antagonistic to leptin.
引用
收藏
页码：43 / 46
页数：4
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