Folate receptor targeted chitosan and polydopamine coated mesoporous silica nanoparticles for photothermal therapy and drug delivery

被引：4
作者：
Bhartiya, Prabha [1 ]
Chawla, Ruchi [1 ]
Dutta, Pradip Kumar [1 ]
机构：
[1] Motilal Nehru Natl Inst Technol Allahabad, Dept Chem, Polymer Res Lab, Allahabad, Uttar Pradesh, India
来源：
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY | 2022年 / 59卷 / 12期
关键词：
Chitosan; Folate receptor; Polydopamine; Mesoporous silica; Nanoparticles; Photothermal therapy; Drug delivery; IN-VITRO; PH; STIMULI; SYSTEM; RELEASE;
D O I：
10.1080/10601325.2022.2135443
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The present work describes the folate receptor targeted chitosan and polydopamine coated mesoporous silica nanoparticles (CS-FA@PDA@MSN) for photothermal therapy and drug delivery. The developed therapeutic diagnostic nanocarrier is used to combat multidrug resistance of cancer in combination with photothermal effect. The nanocarrier exhibited high ability to transport quercetin (Q) into A549 cells through specific targeting ability via recognition through folate receptors expressed on cancer cells and stimulated drug release in its specific acidic environment. In addition, CS-FA@PDA@MSN-Q showed exceptional photothermal effect and as a consequence high cytotoxicity on A549 cells when stimulated by 808 nm laser. These outcomes may provide new possibilities and guidance for reversing multidrug resistance of cancer.
引用
收藏
页码：810 / 817
页数：8
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