Distinction of brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy

被引：43

作者：

Yong, WH

Butte, PV

Pikul, BK

Jo, JA

Fang, QY

Papaioannou, T

Black, KL

Marcu, L

机构：

[1] Cedars Sinai Med Ctr, Dept Surg, Biophoton Res Lab, Maxim Dunitz Neurosurg Inst, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Pathol, Los Angeles, CA 90048 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90048 USA

[4] Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA

[5] Univ So Calif, Dept Elect Engn, Los Angeles, CA 90089 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2006年 / 11卷

关键词：

glioblastoma; glioma; fluorescence spectroscopy; optical diagnostic; brain; tumors; diagnosis;

D O I：

10.2741/1878

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuropathology frozen section diagnoses are difficult in part because of the small tissue samples and the paucity of adjunctive rapid intraoperative stains. This study aims to explore the use of time-resolved laser-induced fluorescence spectroscopy as a rapid adjunctive tool for the diagnosis of glioma specimens and for distinction of glioma from normal tissues intraoperatively. Ten low grade gliomas, 15 high grade gliomas without necrosis, 6 high grade gliomas with necrosis and/or radiation effect, and 14 histologically uninvolved "normal" brain specimens are spectroscopicaly analyzed and contrasted. Tissue autofluorescence was induced with a pulsed Nitrogen laser (337 nm, 1.2 ns) and the transient

引用

页码：1255 / 1263

页数：9

共 22 条

[1] FLUORESCENCE IMAGING AND POINT MEASUREMENTS OF TISSUE - APPLICATIONS TO THE DEMARCATION OF MALIGNANT-TUMORS AND ATHEROSCLEROTIC LESIONS FROM NORMAL TISSUE [J].