Integrin β1 mediates epithelial growth factor-induced invasion in human ovarian cancer cells

被引：28

作者：

Lau, Man-Tat ^{[1
]}

So, Wai-Kin ^{[1
]}

Leung, Peter C. K. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Obstet & Gynecol, Child & Family Res Inst, Vancouver, BC V6H 3N1, Canada

来源：

CANCER LETTERS | 2012年 / 320卷 / 02期

基金：

加拿大健康研究院;

关键词：

EGF; ITGB1; MAPK/ERK; Ovarian cancer; EXTRACELLULAR-MATRIX; RECEPTOR EXPRESSION; BETA-1-INTEGRIN; ADHESION; MIGRATION; PATHWAY; FAMILY; SNAIL; CD44; MAPK;

D O I：

10.1016/j.canlet.2012.02.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Integrins function as cell-extracellular matrix adhesion proteins and have been implicated in tumor progression. In ovarian tumors, elevated integrin beta 1 expression correlates with high clinical stage and poor patient survival. In this study, we report that EGF treatment up-regulated integrin beta 1 mRNA and protein levels in ovarian cancer cells. Moreover, pharmacological inhibition of MEK totally abolished EGF-induced integrin beta 1 up-regulation and cell invasion suggesting that MAPK/ERK signaling is required for EGF-induced integrin beta 1 up-regulation and cell invasion. Furthermore, we found that knockdown of integrin beta 1 expression reduced the intrinsic invasiveness of ovarian cancer cells and the EGF-induced cell invasion. Finally, we found that overexpression of integrin beta 1 was sufficient to promote ovarian cancer cell invasion. This study demonstrates that integrin beta 1 mediates EGF-induced cell invasion in ovarian cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：198 / 204

页数：7

共 29 条

[1] Ascites induces modulation of α6β1 integrin and urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma [J].