Insight into DEG/ENaC Channel Gating from Genetics and Structure

被引：55
作者：
Eastwood, Amy L. [1 ]
Goodman, Miriam B. [1 ]
机构：
[1] Stanford Univ, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA
来源：
PHYSIOLOGY | 2012年 / 27卷 / 05期
关键词：
EPITHELIAL SODIUM-CHANNEL; ACID-SENSING ION-CHANNEL-1; ION-CHANNEL; EXTRACELLULAR DOMAIN; NA+ CHANNEL; PORE REGION; TRANSMEMBRANE DOMAIN; SELECTIVITY FILTER; CRYSTAL-STRUCTURE; MEC-4;
D O I：
10.1152/physiol.00006.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The founding members of the superfamily of DEG/ENaC ion channel proteins are C. elegans proteins that form mechanosensitive channels in touch and pain receptors. For more than a decade, the research community has used mutagenesis to identify motifs that regulate gating. This review integrates insight derived from unbiased in vivo mutagenesis screens with recent crystal structures to develop new models for activation of mechanically gated DEGs.
引用
收藏
页码：282 / 290
页数：9
相关论文
共 74 条
  • [51] Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channel
    Li, Tianbo
    Yang, Youshan
    Canessa, Cecilia M.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2010, 299 (01): : C66 - C73
  • [52] Interaction of the Aromatics Tyr-72/Trp-288 in the Interface of the Extracellular and Transmembrane Domains Is Essential for Proton Gating of Acid-sensing Ion Channels
    Li, Tianbo
    Yang, Youshan
    Canessa, Cecilia M.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (07) : 4689 - 4694
  • [53] Interaction between a putative mechanosensory membrane channel and a collagen
    Liu, JD
    Schrank, B
    Waterston, RH
    [J]. SCIENCE, 1996, 273 (5273) : 361 - 364
  • [54] The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
    O'Hagan, R
    Chalfie, M
    Goodman, MB
    [J]. NATURE NEUROSCIENCE, 2005, 8 (01) : 43 - 50
  • [55] Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating
    Perozo, E
    Kloda, A
    Cortes, DM
    Martinac, B
    [J]. NATURE STRUCTURAL BIOLOGY, 2002, 9 (09) : 696 - 703
  • [56] Poole K, 2011, HANDBOOK OF TOUCH: NEUROSCIENCE, BEHAVIORAL, AND HEALTH PERSPECTIVES, P59
  • [57] Psalmotoxin-1 Docking to Human Acid-sensing Ion Channel-1
    Qadri, Yawar J.
    Berdiev, Bakhrom K.
    Song, Yuhua
    Lippton, Howard L.
    Fuller, Catherine M.
    Benos, Dale J.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (26) : 17625 - 17633
  • [58] A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na plus self inhibition
    Rauh, Robert
    Diakov, Alexei
    Tzschoppe, Anja
    Korbmacher, Judit
    Azad, Abul Kalam
    Cuppens, Harry
    Cassiman, Jean-Jaques
    Doetsch, Joerg
    Sticht, Heinrich
    Korbmacher, Christoph
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2010, 588 (08): : 1211 - 1225
  • [59] Temperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenance
    Royal, DC
    Bianchi, L
    Royal, MA
    Lizzio, M
    Mukherjee, G
    Nunez, YO
    Driscoll, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (51) : 41976 - 41986
  • [60] The GxxxG motif: A framework for transmembrane helix-helix association
    Russ, WP
    Engelman, DM
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2000, 296 (03) : 911 - 919
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