Insight into DEG/ENaC Channel Gating from Genetics and Structure

被引：55
作者：
Eastwood, Amy L. [1 ]
Goodman, Miriam B. [1 ]
机构：
[1] Stanford Univ, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA
来源：
PHYSIOLOGY | 2012年 / 27卷 / 05期
关键词：
EPITHELIAL SODIUM-CHANNEL; ACID-SENSING ION-CHANNEL-1; ION-CHANNEL; EXTRACELLULAR DOMAIN; NA+ CHANNEL; PORE REGION; TRANSMEMBRANE DOMAIN; SELECTIVITY FILTER; CRYSTAL-STRUCTURE; MEC-4;
D O I：
10.1152/physiol.00006.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The founding members of the superfamily of DEG/ENaC ion channel proteins are C. elegans proteins that form mechanosensitive channels in touch and pain receptors. For more than a decade, the research community has used mutagenesis to identify motifs that regulate gating. This review integrates insight derived from unbiased in vivo mutagenesis screens with recent crystal structures to develop new models for activation of mechanically gated DEGs.
引用
收藏
页码：282 / 290
页数：9
相关论文
共 74 条
  • [1] Second transmembrane domain modulates epithelial sodium channel gating in response to shear stress
    Abi-Antoun, Tania
    Shi, Shujie
    Tolino, Lindsey A.
    Kleyman, Thomas R.
    Carattino, Marcelo D.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2011, 300 (05) : F1089 - F1095
  • [2] Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration
    Adams, CM
    Snyder, PM
    Price, MP
    Welsh, MJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (46) : 30204 - 30207
  • [3] LOCAL RESPONSES IN PACINIAN CORPUSCLES
    ALVAREZBUYLLA, R
    DEARELLANO, JR
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1953, 172 (01): : 237 - 244
  • [4] The DEG/ENaC Protein MEC-10 Regulates the Transduction Channel Complex in Caenorhabditis elegans Touch Receptor Neurons
    Arnadottir, Johanna
    O'Hagan, Robert
    Chen, Yushu
    Goodman, Miriam B.
    Chalfie, Martin
    [J]. JOURNAL OF NEUROSCIENCE, 2011, 31 (35) : 12695 - 12704
  • [5] Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1)
    Babini, E
    Paukert, M
    Geisler, HS
    Gründer, S
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (44) : 41597 - 41603
  • [6] Baconguis I, NATURE IN PRESS
  • [7] Zn2+ and H+ are coactivators of acid-sensing ion channels
    Baron, A
    Schaefer, L
    Lingueglia, E
    Champigny, G
    Lazdunski, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) : 35361 - 35367
  • [8] Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel
    Bass, RB
    Strop, P
    Barclay, M
    Rees, DC
    [J]. SCIENCE, 2002, 298 (5598) : 1582 - 1587
  • [9] A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
    Bohlen, Christopher J.
    Chesler, Alexander T.
    Sharif-Naeini, Reza
    Medzihradszky, Katalin F.
    Zhou, Sharleen
    King, David
    Sanchez, Elda E.
    Burlingame, Alma L.
    Basbaum, Allan I.
    Julius, David
    [J]. NATURE, 2011, 479 (7373) : 410 - U167
  • [10] Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotranscluction channel alter gating and drug blockade
    Brown, Austin L.
    Fernandez-Illescas, Silvia M.
    Liao, Zhiwen
    Goodman, Miriam B.
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 2007, 129 (02) : 161 - 173
12345678