Involvement of the insular cortex in regulating glucocorticoid effects on memory consolidation of inhibitory avoidance training

被引：35

作者：

Fornari, Raquel V. ^{[1
,2
]}

Wichmann, Romy ^{[1
]}

Atucha, Erika ^{[1
]}

Desprez, Tifany ^{[1
]}

Eggens-Meijer, Ellie ^{[1
]}

Roozendaal, Benno ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Sect Anat, Dept Neurosci, NL-9713 AV Groningen, Netherlands

[2] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Nucleo Cognicao & Sistemas Complexos, Santo Andre, SP, Brazil

来源：

FRONTIERS IN BEHAVIORAL NEUROSCIENCE | 2012年 / 6卷

关键词：

stress; emotional memory; corticosterone; pERK; insula; glucocorticoid receptor; CONDITIONED TASTE-AVERSION; ACTIVATED PROTEIN-KINASE; MEDIAL PREFRONTAL CORTEX; LONG-TERM-MEMORY; BASOLATERAL AMYGDALA; UNFAMILIAR TASTE; MAPK CASCADE; STRESS; HIPPOCAMPUS; ACQUISITION;

D O I：

10.3389/fnbeh.2012.00010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Glucocorticoids are known to enhance the consolidation of memory of emotionally arousing experiences by acting upon a network of interconnected brain regions. Although animal studies typically do not consider the insular cortex (IC) to be part of this network, the present findings indicate that the IC is importantly involved in regulating glucocorticoid effects on memory consolidation of emotionally arousing inhibitory avoidance training. The specific glucocorticoid receptor (GR) agonist RU 28362 (3 or 10 ng in 0.5 mu l) infused bilaterally into the IC of male SpragueDawley rats immediately after one-trial inhibitory avoidance training dose-dependently enhanced 48 h retention performance. Moreover, training on the inhibitory avoidance task increased neuronal activity of the IC, as assessed by an increased number of cells expressing immunoreactivity for phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2). However, systemic administration of a memory-enhancing dose of corticosterone (1 mg/kg) after inhibitory avoidance training rapidly reduced the number of pERK1/2-positive cells in the IC, suggesting that glucocorticoid administration reduces overall neuronal activity of the IC. To investigate which components of the inhibitory avoidance training experience were influenced by the intra-IC glucocorticoid administration, in the last experiment rats were trained on a modified inhibitory avoidance task in which context exposure and footshock training occur on two sequential days. RU 28362 administration into the IC enhanced later retention when infused immediately after either the context or footshock training. Thus, these findings indicate that the IC mediates glucocorticoid effects on the consolidation of memory of different components of inhibitory avoidance training and suggest that the IC might be an important element of the rodent brain network involved in emotional regulation of learning and memory.

引用

页数：11