Epigenetic alterations of testicular germ cell tumours

被引：8

作者：

Ilijazi, Dafina ^{[1
]}

Shariat, Shahrok F. ^{[1
,2
,3
,4
,5
]}

Hassler, Melanie R. ^{[1
]}

Lemberger, Ursula ^{[1
]}

Ertl, Iris E. ^{[1
]}

机构：

[1] Med Univ Vienna, Ctr Comprehens Canc, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

[2] Weill Cornell Med Coll, Dept Urol, New York, NY USA

[3] Univ Texas Southwestern, Dept Urol, Dallas, TX USA

[4] Charles Univ Prague, Fac Med 2, Dept Urol, Prague, Czech Republic

[5] IM Sechenov First Moscow State Med Univ, Inst Urol & Reprod Hlth, Moscow, Russia

来源：

CURRENT OPINION IN UROLOGY | 2020年 / 30卷 / 02期

关键词：

DNA methylation; epigenetics; microRNAs; nonseminoma; seminoma; NEOPLASIA IN-SITU; SERUM-LEVELS; PROMOTER METHYLATION; EXPRESSION; BIOMARKER; CHEMOTHERAPY; ONCOGENES; APOPTOSIS; PATTERNS; GROWTH;

D O I：

10.1097/MOU.0000000000000724

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Testicular germ cell tumours (TGCTs) exhibit, in contrast to other cancer types, a relatively low mutational burden. However, numerous epigenetic alterations have been shown to impact TGCT. In this review, we summarize the most relevant findings of the past 2 years. Recent findings Recent studies focused on the functions of microRNAs and the impact of aberrant DNA methylation. Moreover, several epigenetic drugs with antineoplastic effects in TGCTs were identified. Aberrant DNA methylation and differentially expressed microRNAs have an important effect on TGCT pathogenesis. Moreover, differential DNA methylation patterns were found to be specific for different TGCT subtypes. Various microRNAs, such as miR-371a-3p, were found to be highly sensitive and specific biomarkers for TGCT. The epigenetic drugs guadecitabine, animacroxam, and JQ1 showed promising effects on TGCT in preclinical in-vivo and in-vitro studies.

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收藏

页码：264 / 270

页数：7

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