Morphometric changes in the episodic memory network and tau pathologic features correlate with memory performance in patients with mild cognitive impairment

被引：46

作者：

Fjell, A. M. ^{[1
]}

Walhovd, K. B. ^{[1
]}

Amlien, I. ^{[1
]}

Bjornerud, A. ^{[2
,3
]}

Reinvang, I. ^{[1
]}

Gierstad, L. ^{[4
]}

Cappelen, T. ^{[5
]}

Willoch, F. ^{[6
]}

Due-Tonnessen, P. ^{[3
]}

Grambaite, R. ^{[7
]}

Skinningsrud, A. ^{[8
]}

Stenset, V. ^{[7
]}

Fladby, T. ^{[7
]}

机构：

[1] Univ Oslo, Dept Psychol, N-0317 Oslo, Norway

[2] Univ Oslo, Dept Phys, N-0317 Oslo, Norway

[3] Rikshosp Univ Hosp, Dept Radiol, Oslo, Norway

[4] Rikshosp Univ Hosp, Dept Neurol, Oslo, Norway

[5] Rikshosp Univ Hosp, Dept Nucl Med, Oslo, Norway

[6] Aker Univ Hosp, Dept Radiol, Oslo, Norway

[7] Akershus Univ Hosp, Dept Neurol, Fac Div, Lorenskog, Norway

[8] Akershus Univ Hosp, Dept Clin Chem & Nucl Med, Lorenskog, Norway

来源：

AMERICAN JOURNAL OF NEURORADIOLOGY | 2008年 / 29卷 / 06期

关键词：

D O I：

10.3174/ajnr.A1059

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BACKGROUND AND PURPOSE: Mild cognitive impairment (MCI) may affect several cognitive domains, including attention and reasoning, but is often first characterized by memory deficits. The purpose of this study was to ask these 2 questions: 1) Can levels of CSF tau proteins and amyloid beta 42 peptide explain thinning of the cerebral cortex in patients with MCI? 2) How are brain morphometry, CSF biomarkers, and apolipoprotein E (APOE) allelic variation related to episodic memory function in MCI? MATERIALS AND METHODS: Hippocampal volume and cortical thickness were estimated by MR imaging and compared for patients with MCI (n = 18) and healthy controls (n = 18). In addition, regions of interest (ROIs) were selected in areas where the MCI group had atrophy and which overlapped with the episodic memory network (temporal, entorhinal, inferior parietal, precuneus/posterior cingulate, and frontal). Relationships among morphometry, CSF biomarkers, APOE, and memory were tested. The analyses were repeated with an independent sample of patients with MCI (n = 19). RESULTS: Patients with MCI and pathologic CSF values had hippocampal atrophy. However, both patients with pathologic and patients with nonpathologic CSF had a thinner cortex outside the hippocampal area. CSF pathology was related to hippocampal volume, whereas relationships with cortical thickness were found mainly in one of the samples. Morphometry correlated robustly with memory performance across MCI samples, whereas less stable results were found for tau protein. CONCLUSION: The differences in hippocampal volume between the MCI and the healthy control groups were only found in patients with pathologic CSF biomarkers, whereas differences in cortical thickness were also found for patients without such pathologic features. Morphometry in areas in the episodic memory network was robustly correlated with memory performance. It is speculated that atrophy in these areas may be associated with the memory problems seen in MCI.

引用

页码：1183 / 1189

页数：7

共 57 条

[1] Differential CSF biomarker levels in APOE-ε4-positive and -negative patients with memory impairment [J].