Alcohol consumption and the risk of renal cancers in the European prospective investigation into cancer and nutrition (EPIC)

被引：32

作者：

Wozniak, Magdalena B. ^{[1
]}

Brennan, Paul ^{[1
]}

Brenner, Darren R. ^{[1
,2
]}

Overvad, Kim ^{[3
]}

Olsen, Anja ^{[4
]}

Tjonneland, Anne ^{[4
]}

Boutron-Ruault, Marie-Christine ^{[5
,6
]}

Clavel-Chapelon, Francoise ^{[5
,6
]}

Fagherazzi, Guy ^{[5
,6
]}

Katzke, Verena ^{[7
]}

Kuehn, Tilman ^{[7
]}

Boeing, Heiner ^{[8
]}

Bergmann, Manuela M. ^{[8
]}

Steffen, Annika ^{[8
]}

Naska, Androniki ^{[9
,10
]}

Trichopoulou, Antonia ^{[9
,10
,11
]}

Trichopoulos, Dimitrios ^{[10
,11
,12
]}

Saieva, Calogero ^{[13
]}

Grioni, Sara ^{[14
]}

Panico, Salvatore ^{[15
]}

Tumino, Rosario ^{[16
,17
]}

Vineis, Paolo ^{[18
,19
]}

Bueno-de-Mesquita, H. B ^{[18
,20
,21
,22
]}

Peeters, Petra H. ^{[23
]}

Hjartaker, Anette ^{[24
]}

Weiderpass, Elisabete ^{[25
,26
,27
,28
]}

Arriola, Larraitz ^{[29
]}

Molina-Montes, Esther ^{[30
,31
]}

Duell, Eric J. ^{[32
]}

Santiuste, Carmen ^{[33
]}

Alonso de la Torre, Ramon ^{[34
]}

Barricarte Gurrea, Aurelio ^{[35
,36
]}

Stocks, Tanja ^{[37
,38
]}

Johansson, Mattias ^{[1
,38
]}

Ljungberg, Borje ^{[38
]}

Wareham, Nick ^{[39
]}

Khaw, Kay-Tee ^{[40
]}

Travis, Ruth C. ^{[41
]}

Cross, Amanda J. ^{[18
]}

Murphy, Neil ^{[18
]}

Riboli, Elio ^{[18
]}

Scelo, Ghislaine ^{[1
]}

机构：

[1] Int Agcy Res Canc, Genet Epidemiol Grp, F-69372 Lyon 08, France

[2] Alberta Hlth Serv, Canc Control Alberta, Dept Populat Hlth Res, Calgary, AB, Canada

[3] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark

[4] Danish Canc Soc, Res Ctr, Dept Diet Genes & Environm, Copenhagen, Denmark

[5] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Villejuif, France

[6] Univ Paris 11, INSERM, Inst Gustave Roussy, Villejuif, France

[7] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[8] German Inst Human Nutr DIfE Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[9] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[10] Hellen Hlth Fdn, Athens, Greece

[11] Acad Athens, Bur Epidemiol Res, Athens, Greece

[12] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[13] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[14] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[15] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[16] ASP Ragusa, Civ MP Arezzo Hosp, Canc Registry, Naples, Italy

[17] ASP Ragusa, Civ MP Arezzo Hosp, Histopathol Unit, Naples, Italy

[18] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London SW7 2AZ, England

[19] HuGeF Fdn, Turin, Italy

[20] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands

[21] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[22] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[23] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC PHE, London SW7 2AZ, England

[24] Univ Oslo, Dept Nutr, Inst Basic Med Sci, Oslo, Norway

[25] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[26] Canc Registry Norway, Oslo, Norway

[27] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[28] Folkhalsan Res Ctr, Dept Genet Epidemiol, Helsinki, Finland

[29] CIBER Epidemiol & Salud Publ, Basque Govt, Inst BIO Donostia, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[30] Univ Granada, Inst Invest Biosanitaria, Escuela Andaluza Salud Publ, Granada, Spain

[31] CIBER Epidemiol & Salud Publ, Granada, Spain

[32] Catalan Inst Oncol ICO, Unit Nutr Environm & Canc, Canc Epidemiol Res Program, Barcelona, Spain

[33] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[34] Publ Hlth Directorate, Asturias, Spain

[35] Navarre Publ Hlth Inst, Pamplona, Spain

[36] CIBER Epidemiol & Salud Publ, Madrid, Spain

[37] Lund Univ, Dept Clin Sci, Malmo, Sweden

[38] Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden

[39] Univ Cambridge, Dept Publ Hlth & Primary Care, MRC, Epidemiol Unit, Cambridge, England

[40] Univ Cambridge, Sch Clin Med, Cambridge, England

[41] Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2015年 / 137卷 / 08期

基金：

欧洲研究理事会; 英国医学研究理事会;

关键词：

kidney cancer; renal cell carcinoma; risk factors; alcohol consumption; EPIC; cohort study; CELL CARCINOMA; KIDNEY CANCER; FLUID INTAKE; DRINKING; EPIDEMIOLOGY; COUNTRIES; DIET; METAANALYSIS; OVERWEIGHT; MORTALITY;

D O I：

10.1002/ijc.29559

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 through to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n=931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment versus the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), 0.91 (0.63-1.30), respectively, (p(trend)=0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer. What's new? Previous studies have indicated that environmental or lifestyle factors may be involved in the etiology of renal cancer, and that moderate alcohol consumption may reduce the risk of this type of cancer. In this very large European study (nearly 500,000 subjects), the authors found that, indeed, total alcohol consumption was inversely associated with renal cancer overall (for all subsites combined), and also with cancers of the renal parenchyma.

引用

页码：1953 / 1966

页数：14

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