Identification of Circulating MiR-25 as a Potential Biomarker for Pancreatic Cancer Diagnosis

被引：61

作者：

Deng, Ting ^{[1
,2
,3
]}

Yuan, Yaozong ^{[4
]}

Zhang, Chunni ^{[5
]}

Zhang, Chenyu ^{[6
]}

Yao, Weiyan ^{[4
]}

Wang, Cheng ^{[5
]}

Liu, Rui ^{[1
,2
,3
]}

Ba, Yi ^{[1
,2
,3
]}

机构：

[1] Tianjin Med Univ, Canc Inst & Hosp, Dept Gastrointestinal Med Oncol, Tianjin 300060, Peoples R China

[2] Natl Clin Res Ctr Canc, Tianjin, Peoples R China

[3] Key Lab Canc Prevent & Therapy Tianjin, Tianjin, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Gastroenterol, Shanghai, Peoples R China

[5] Nanjing Univ, Clin Sch Med Coll, Jinling Hosp, Dept Clin Lab, Nanjing, Jiangsu, Peoples R China

[6] Nanjing Univ, Jiangsu Engn Res Ctr microRNA Biol & Biotechnol, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing, Jiangsu, Peoples R China

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2016年 / 39卷 / 05期

基金：

中国国家自然科学基金;

关键词：

MiR-25; Pancreatic cancer; Serum; Biomarker; Circulating microRNAs; DUCTAL ADENOCARCINOMA GROWTH; MICRORNA BIOMARKERS; EXPRESSION; APOPTOSIS; PROFILE; BLOOD;

D O I：

10.1159/000447872

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Background: The aim of this study was to identify novel microRNAs for potential use in the diagnosis of pancreatic cancer (PaC). Methods: A total of 1063 serum samples from 303 patients with PaC were collected, and the expression level of miR-25 was measured using quantitative real-time PCR (qRT-PCR). Results: We found that miR-25 had significant diagnostic value for the differential diagnosis of PaC in normal controls with an AUC (the area under the ROC curve) of 0.915 (95% CI: 0.893-0.937) that was significantly higher compared with an AUC of 0.725 for serum tumor marker carcinoembryonic antigen (CEA) and an AUC of 0.844 for CA19-9. Conclusions: These data suggest that serum miR-25 has strong potential as a novel biomarker for the early detection of PaC. (C) 2016 The Author(s) Published by S. Karger AG, Basel

引用

页码：1716 / 1722

页数：7

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