Fe3O4@SiO2/EP.EN.EG.Cu as a Highly Efficient and Recoverable Catalytic System for Synthesis of 1,4-Disubstituted 1,2,3-Triazole Derivatives via the Click Reaction

A magnetic nanostructured core-shell Fe3O4@SiO2/EP.EN.EG.Cu has used as an efficient heterogeneous catalyst for the synthesis of 1,4-disubstituted 1,2,3-triazole derivatives through click reaction, under mild reaction conditions. A variety of epoxides, alkyl or benzyl halides was used to afford the corresponding 1,4-disubstituted 1,2,3-triazoles. The catalyst could be easily separated by using an external magnet from the reaction mixture and reused seven times without significant loss of catalytic activity.