Screening patterns within organized programs and survival of Italian women with invasive cervical cancer

被引：36

作者：

Zucchetto, Antonella ^{[1
,2
]}

Ronco, Guglielmo ^{[3
]}

Rossi, Paolo Giorgi ^{[4
]}

Zappa, Marco ^{[5
]}

Ferretti, Stefano ^{[6
,7
]}

Franzo, Antonella ^{[8
]}

Falcini, Fabio ^{[9
]}

Visioli, Carmen Beatriz ^{[5
]}

Zanetti, Roberto

Biavati, Patrizia ^{[10
]}

La Rosa, Francesco ^{[11
]}

Baracco, Susanna ^{[12
]}

Federico, Massimo ^{[10
,13
]}

Campari, Cinzia

De Togni, Aldo ^{[7
]}

Piffer, Silvano ^{[14
]}

Pannozzo, Fabio ^{[15
]}

Fusco, Mario ^{[16
]}

Michiara, Maria ^{[17
]}

Castaing, Marine ^{[18
]}

Seghini, Pietro ^{[19
]}

Tisano, Francesco ^{[20
]}

Serraino, Diego ^{[1
]}

机构：

[1] Aviano Natl Canc Inst, Ctr Riferimento Oncol, Epidemiol & Biostat Unit, I-33081 Aviano, Italy

[2] Univ Milan, Clin Sci & Community Hlth, I-20133 Milan, Italy

[3] Oncol Prevent Ctr, I-10123 Turin, Italy

[4] Reggio Emilia Local Healt Unit, I-42122 Reggio Emilia, Italy

[5] Canc Prevent & Res Ist ISPO, I-50141 Florence, Italy

[6] Univ Ferrara, Ferrara Canc Registry, I-44100 Ferrara, Italy

[7] Ferrara Local Hlth Unit, I-44100 Ferrara, Italy

[8] Friuli Venezia Giulia Cent Hlth Direct, I-33100 Udine, Italy

[9] IRST, Canc Inst Romagna, I-47014 Meldola, Italy

[10] Bologna Local Hlth Unit, I-40124 Bologna, Italy

[11] Univ Perugia, Sect Publ Hlth, Dept Med & Surg Specialties & Publ Hlth, Umbria Canc Registry, I-06100 Perugia, Italy

[12] Ist Oncol Veneto IRCCS, Veneto Canc Registry, I-35128 Padua, Italy

[13] Univ Modena & Reggio Emilia, Dept Oncol Hematol & Resp Dis, Modena Canc Registry, I-41121 Modena, Italy

[14] Azienda Provinciale Servizi Sanitari, Epidemiol Unit, I-38100 Trento, Italy

[15] Latina Hlth Author, Latina Prov Canc Registry, I-04100 Latina, Italy

[16] Campania Canc Registry, Local Hlth Unit 4, I-80031 Brusciano, Italy

[17] Univ Hosp Parma, Parma Prov Canc Registry, I-43100 Parma, Italy

[18] Catania Univ Hosp, Catania Messina Canc Registry, I-95123 Catania, Italy

[19] Piacenza Canc Registry, Piacenza Local Hlth Unit, I-29121 Piacenza, Italy

[20] Siracusa Local Hlth Unit, Siracusa Canc Registry, I-96100 Siracusa, Italy

来源：

PREVENTIVE MEDICINE | 2013年 / 57卷 / 03期

关键词：

Cervical cancer; Organized screening program; Screening history; Cytology; HISTORY;

D O I：

10.1016/j.ypmed.2013.05.018

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objectives. To evaluate screening patterns within organized cervical screening programs (OCSPs) and survival of women with invasive cervical cancer (ICC). Methods. A population-based study was conducted in Italian areas covered by cancer registries and OCSPs. The study included all women aged 25-65 years diagnosed with ICC between 1995 and 2008, and their screening histories within OCSPs were retrieved. Hazard ratios (HR) of death and 95% confidence intervals (Cl) were computed according to screening pattern, using Cox models adjusted for age, ICC stage, and major confounders. Results. Among 3268 women with ICC, 20% were never-invited to OCSP, 36% were never-compliant with OCSP's invitation, 33% were compliant and had a screen-detected ICC within OCSP (i.e., after a positive cytology), and 11% were compliant but had a non-screen-detected ICC. Screen-detected ICCs were more frequently micro-invasive (42%) compared to non-screen-detected ones (14%). Compared to women with screen-detected ICC, the adjusted HRs of death were 1.9 (95% Cl 15-2.4) for those never-invited, 2.0 (95% CI 1.6-2.5) for never-compliant, and 1.7 (95% CI 13-2.4) for compliant women having non-screen-detected ICC. Conclusion. Prolonged survival, beyond down-staging, of women with ICC detected within OCSPs in Italy, further calls for improvements of OCSPs' invitational coverage and participation. CI (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：220 / 226

页数：7

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