Nocturnal hypertension and dysautonomia in patients with Parkinson's disease: are they related?

被引:54
作者
Berganzo, Koldo [1 ,2 ]
Diez-Arrola, Begona [3 ]
Tijero, Beatriz [1 ,2 ]
Somme, Johanne [4 ]
Lezcano, Elena [1 ,2 ]
Llorens, Veronica [5 ]
Ugarriza, Iratxe [1 ,2 ]
Ciordia, Roberto [1 ,2 ]
Gomez-Esteban, J. C. [1 ,2 ]
Zarranz, Juan J. [1 ,2 ]
机构
[1] Cruces Univ Hosp, Basque Hlth Serv Osakidetza, Neurol Serv, Auton & Movement Disorders Unit, Baracaldo 48903, Spain
[2] Univ Basque Country, Dept Neurosci, Leioa, Spain
[3] Biscaye Parkinsons Dis Soc, Bilbao, Spain
[4] Alava Univ Hosp, Dept Neurol, Vitoria, Spain
[5] Cruces Univ Hosp, Nucl Med Serv, Baracaldo 48903, Spain
关键词
Parkinson disease; Autonomic disorders; Nocturnal hypertension; 24-h ambulatory blood pressure monitoring (ABPM); Dopaminergic treatment; ORTHOSTATIC HYPOTENSION; BLOOD-PRESSURE; AUTONOMIC FAILURE; RISK; ASSOCIATION;
D O I
10.1007/s00415-013-6859-5
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Orthostatic hypotension and supine hypertension frequently coexist in Parkinson's disease (PD) patients, leading to visceral damage and increased mortality rates. The aim of this paper is to analyze the frequency and association of both conditions in a sample of outpatients with PD. A total of 111 patients, diagnosed with PD, were studied. Disease duration, treatment, cardiovascular risk factors, UPDRS I-IV and Scopa Aut scale scores were reported. Subjects underwent 24-h ambulatory blood pressure (BP) monitoring and were assessed for orthostatic hypotension. We compared our results with those published in 17,219 patients using the same protocol and the same type of device. Overall, 71.1 % had no proper circadian rhythm. This frequency was significantly higher than that of the control population (48 %). The prevalence of the nondipper or riser patterns was higher in patients with orthostatic hypotension (77.8 vs. 66.7 %). There was a correlation between nightly increases in diastolic blood pressure and changes in BP during the orthostatic test. Patients taking higher doses of treatment had less decreases in SBP (cc:-0.25; p = 0.007) and DBP (cc:-0.33; p < 0.001) at night, however there was no relation with drug type. The majority of patients with Parkinson's disease show an altered circadian rhythm of blood pressure. Patients with a non-dipper or riser pattern on 24 h ABPM exhibited a higher prevalence of autonomic disorders (orthostatic hypotension) and received higher doses of dopaminergic treatment. A day-night variation in diastolic blood pressure was the most important marker of these findings.
引用
收藏
页码:1752 / 1756
页数:5
相关论文
共 19 条
  • [1] Use of antihypertensives and the risk of Parkinson disease
    Becker, Claudia
    Jick, Susan S.
    Meier, Christoph R.
    [J]. NEUROLOGY, 2008, 70 (16) : 1438 - 1444
  • [2] SCOPA-AUT scale in different parkinsonisms and its correlation with (123) I-MIBG cardiac scintigraphy
    Berganzo, Koldo
    Tijero, Beatriz
    Somme, Johanne H.
    Llorens, Veronica
    Sanchez-Manso, Juan C.
    Low, David
    Iodice, Valeria
    Vichayanrat, Ekawat
    Mathias, Christopher J.
    Lezcano, Elena
    Zarranz, Juan J.
    Gomez-Esteban, Juan C.
    [J]. PARKINSONISM & RELATED DISORDERS, 2012, 18 (01) : 45 - 48
  • [3] A randomized trial of deep-brain stimulation for Parkinson's disease
    Deuschl, Guenther
    Schade-Brittinger, Carmen
    Krack, Paul
    Volkmann, Jens
    Schaefer, Helmut
    Boetzel, Kai
    Daniels, Christine
    Deutschlaender, Angela
    Dillmann, Ulrich
    Eisner, Wilhelm
    Gruber, Doreen
    Hamel, Wolfgang
    Herzog, Jan
    Hilker, Ruediger
    Klebe, Stephan
    Kloss, Manja
    Koy, Jan
    Krause, Martin
    Kupsch, Andreas
    Lorenz, Delia
    Lorenzl, Stefan
    Mehdorn, H. Maximilian
    Moringlane, Jean Richard
    Oertel, Wolfgang
    Pinsker, Marcus O.
    Reichmann, Heinz
    Reuss, Alexander
    Schneider, Gerd-Helge
    Schnitzler, Alfons
    Steude, Ulrich
    Sturm, Volker
    Timmermann, Lars
    Tronnier, Volker
    Trottenberg, Thomas
    Wojtecki, Lars
    Wolf, Elisabeth
    Poewe, Werner
    Voges, Juergen
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (09) : 896 - 908
  • [4] Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension - Independence from levodopa treatment
    Goldstein, DS
    Eldadah, BA
    Holmes, C
    Pechnik, S
    Moak, J
    Saleem, A
    Sharabi, Y
    [J]. HYPERTENSION, 2005, 46 (06) : 1333 - 1339
  • [5] Association between supine hypertension and orthostatic hypotension in autonomic failure
    Goldstein, DS
    Pechnik, S
    Holmes, C
    Eldadah, B
    Sharabi, Y
    [J]. HYPERTENSION, 2003, 42 (02) : 136 - 142
  • [6] Ambulatory blood pressure monitoring in hypertensive patients with high cardiovascular risk:: a cross-sectional analysis of a 20,000-patient database in Spain
    Gorostidi, Manuel
    Sobrino, Javier
    Segura, Julian
    Sierra, Cristina
    de la Sierra, Alex
    del Rey, Raquel Hernandez
    Vinyoles, Ernest
    Galceran, Josep M.
    Lopez-Eady, Maria D.
    Marin, Rafael
    Banegas, Jose R.
    Sarria, Antonio
    Coca, Antonio
    Ruilope, Luis M.
    [J]. JOURNAL OF HYPERTENSION, 2007, 25 (05) : 977 - 984
  • [7] Orthostatic Hypotension as a Risk Factor for Incident Heart Failure The Atherosclerosis Risk in Communities Study
    Jones, Christine D.
    Loehr, Laura
    Franceschini, Nora
    Rosamond, Wayne D.
    Chang, Patricia P.
    Shahar, Eyal
    Couper, David J.
    Rose, Kathryn M.
    [J]. HYPERTENSION, 2012, 59 (05) : 913 - 918
  • [8] Kaufmann Horacio, 2007, Handb Clin Neurol, V83, P343, DOI 10.1016/S0072-9752(07)83014-4
  • [9] PSP as Distinguished from CBD, MSA-P and PD by Clinical and Imaging Differences at an Early Stage
    Kurata, Tomoko
    Kametaka, Satsuki
    Ohta, Yasuyuki
    Morimoto, Nobutoshi
    Deguchi, Shoko
    Deguchi, Kentaro
    Ikeda, Yoshio
    Takao, Yoshiki
    Ohta, Taisei
    Manabe, Yasuhiro
    Sato, Shuhei
    Abe, Koji
    [J]. INTERNAL MEDICINE, 2011, 50 (22) : 2775 - 2781
  • [10] Maule Simona, 2007, Cardiovascular & Hematological Disorders - Drug Targets, V7, P63