Impact of diabetes on cognitive function and brain structure

被引：347

作者：

Moheet, Amir ^{[1
]}

Mangia, Silvia ^{[2
]}

Seaquist, Elizabeth R. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Med, Div Endocrinol & Diabet, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Radiol, Ctr Magnet Resonance Res, Minneapolis, MN 55455 USA

来源：

YEAR IN DIABETES AND OBESITY | 2015年 / 1353卷

关键词：

type 1 diabetes mellitus; type 2 diabetes mellitus; cognitive dysfunction; brain; memory; RESTING-STATE NETWORKS; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; RISK-FACTORS; CARDIOVASCULAR RISK; DEFAULT MODE; BASE-LINE; MELLITUS; DEMENTIA; DECLINE;

D O I：

10.1111/nyas.12807

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Both type 1 and type 2 diabetes have been associated with reduced performance on multiple domains of cognitive function and with structural abnormalities in the brain. With an aging population and a growing epidemic of diabetes, central nervous system-related complications of diabetes are expected to rise and could have challenging future public health implications. In this review, we will discuss the brain structural and functional changes that have been associated with type 1 and type 2 diabetes. Diabetes duration and glycemic control may play important roles in the development of cognitive impairment in diabetes, but the exact underlying pathophysiological mechanisms causing these changes in cognition and structure are not well understood. Future research is needed to better understand the natural history and the underlying mechanisms, as well as to identify risk factors that predict who is at greatest risk of developing cognitive impairment. This information will lead to the development of new strategies to minimize the impact of diabetes on cognitive function.

引用

页码：60 / 71

页数：12

共 98 条

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