Metabolomics in Alzheimer's disease research

被引：13
作者：
Ibanez, Clara [1 ]
Simo, Carolina [1 ]
Cifuentes, Alejandro [1 ]
机构：
[1] CSIC, Lab Food, CIAL, Madrid 28049, Spain
来源：
ELECTROPHORESIS | 2013年 / 34卷 / 19期
关键词：
Alzheimer's disease; Biomarker; Metabolomics; Mild cognitive impairment; Multivariate statistical analysis; MILD COGNITIVE IMPAIRMENT; HUMAN CEREBROSPINAL-FLUID; MASS-SPECTROMETRY; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATURAL POLYPHENOLS; NATIONAL INSTITUTE; APOLIPOPROTEIN-E; BODY-FLUIDS; BIOMARKERS;
D O I：
10.1002/elps.201200694
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) is a neurodegenerative multifactorial disease whose cause is still unknown. The majority of AD biochemical markers currently available have been developed as an extension of targeted physiological studies on the basis of the amyloid hypothesis. The potential of metabolomics for the discovery of novel biomarkers and elucidation of new biochemical pathways modified in the progression of AD is highlighted in this review work. A variety of nontargeted metabolomic approaches for the discrimination between healthy subjects and AD patients are described. Moreover, the feasibility of metabolomics to predict progression to AD in individuals with mild cognitive impairment is also presented.
引用
收藏
页码：2799 / 2811
页数：13
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