Have drug combinations supplanted stem cell transplantation in myeloma?

被引：9

作者：

Palumbo, Antonio ^{[1
]}

Cavallo, Federica ^{[1
]}

机构：

[1] Univ Turin, Div Hematol, Myeloma Unit, I-10126 Turin, Italy

来源：

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM | 2012年

关键词：

DIAGNOSED MULTIPLE-MYELOMA; HIGH-DOSE THERAPY; LONG-TERM SURVIVAL; AUTOLOGOUS TRANSPLANTATION; CONSOLIDATION THERAPY; PLUS DEXAMETHASONE; INDUCTION THERAPY; ELDERLY-PATIENTS; THALIDOMIDE; BORTEZOMIB;

D O I：

10.1182/asheducation-2012.1.335

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

The introduction of proteasome inhibitor and immunomodulatory drugs has considerably changed the treatment paradigm of multiple myeloma. Autologous stem cell transplantation (ASCT) is superior to conventional chemotherapy and is considered the standard of care for patients younger than 65 years. Nevertheless, the favorable results shown by multidrug inductions, consolidations, and long-term maintenance approaches have challenged the role of ASCT. This article provides an overview of recent and ongoing clinical trials and aims to define the role of ASCT in the era of novel agents.

引用

页码：335 / 341

页数：7

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