Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives

被引：135

作者：

Grandjean, Philippe ^{[1
,4
]}

Barouki, Robert ^{[5
]}

Bellinger, David C. ^{[1
]}

Casteleyn, Ludwine ^{[6
]}

Chadwick, Lisa H. ^{[7
]}

Cordier, Sylvaine ^{[8
]}

Etzel, Ruth A. ^{[9
]}

Gray, Kimberly A. ^{[7
]}

Ha, Eun-Hee ^{[10
]}

Junien, Claudine ^{[11
,12
]}

Karagas, Margaret ^{[13
,14
]}

Kawamoto, Toshihiro ^{[15
]}

Lawrence, B. Paige ^{[16
]}

Perera, Frederica P. ^{[17
,18
]}

Prins, Gail S. ^{[19
]}

Puga, Alvaro ^{[20
]}

Rosenfeld, Cheryl S. ^{[21
]}

Sherr, David H. ^{[22
]}

Sly, Peter D. ^{[23
]}

Suk, William ^{[7
]}

Sun, Qi ^{[2
,3
]}

Toppari, Jorma ^{[24
,25
,26
]}

van den Hazel, Peter ^{[27
]}

Walker, Cheryl L. ^{[28
]}

Heindel, Jerrold J. ^{[7
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Landmark Ctr 3E-110,401 Park Dr, Boston, MA 02115 USA

[2] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA

[4] Univ Southern Denmark, Inst Publ Hlth, Dept Environm Med, DK-5000 Odense, Denmark

[5] Univ Paris 05, Hop Necker Enfants Malad, Assistance Publ Hop Paris, INSERM Unit 1124, F-75015 Paris, France

[6] Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

[7] NIEHS, Div Extramural Res & Training, Res Triangle Pk, NC 27709 USA

[8] Univ Rennes 1, INSERM, Unit 1085, F-35000 Rennes, France

[9] Univ Wisconsin, Joseph J Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA

[10] Ewha Womans Univ, Sch Med, Dept Prevent Med, Seoul 158710, South Korea

[11] INRA, MR Unite Mixte Rech Biol Dev & Reprod 1198, F-78350 Jouy En Josas, France

[12] Univ Versailles St Quentin, F-78000 Versailles, France

[13] Geisel Sch Med Dartmouth, Childrens Environm Hlth & Dis Prevent Res Ctr, Hanover, NH 03766 USA

[14] Geisel Sch Med Dartmouth, Dept Epidemiol, Hanover, NH 03766 USA

[15] Univ Occupat & Environm Hlth, Dept Environm Hlth, Kitakyushu, Fukuoka 8078555, Japan

[16] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY 14642 USA

[17] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY 10032 USA

[18] Columbia Univ, Mailman Sch Publ Hlth, Columbia Ctr Childrens Environm Hlth, New York, NY 10032 USA

[19] Univ Illinois, Dept Urol, Chicago, IL 60612 USA

[20] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA

[21] Univ Missouri, Thompson Ctr Autism & Neurobehav Disorders, Bond Life Sci Ctr, Genet Area Program,Biomed Sci, Columbia, MO 65211 USA

[22] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA

[23] Univ Queensland, Royal Childrens Hosp, Queensland Childrens Med Res Inst, Brisbane, Qld 4006, Australia

[24] Univ Turku, Dept Physiol, Turku 20014, Finland

[25] Univ Turku, Dept Pediat, Turku 20014, Finland

[26] Turku Univ Hosp, Turku 20014, Finland

[27] Int Network Childrens Hlth Environm & Safety, NL-6955 Ellecom, Netherlands

[28] Texas A&M Hlth Sci Ctr, Inst Biosci & Technol, Houston, TX 77030 USA

来源：

ENDOCRINOLOGY | 2015年 / 156卷 / 10期

基金：

美国国家卫生研究院; 美国国家环境保护局;

关键词：

TRANSGENERATIONAL INHERITANCE; DNA METHYLATION; STEM-CELLS; ORIGINS; HEALTH; EPIGENETICS; ESTROGENS; CHEMICALS; RISK;

D O I：

10.1210/EN.2015-1350

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Developmental Origins of Health and Disease (DOHaD) paradigm is one of the most rapidly expanding areas of biomedical research. Environmental stressors that can impact on DOHaD encompass a variety of environmental and occupational hazards as well as deficiency and oversupply of nutrients and energy. They can disrupt early developmental processes and lead to increased susceptibility to disease/dysfunctions later in life. Presentations at the fourth Conference on Prenatal Programming and Toxicity in Boston, in October 2014, provided important insights and led to new recommendations for research and public health action. The conference highlighted vulnerable exposure windows that can occur as early as the preconception period and epigenetics as a major mechanism than can lead to disadvantageous "reprogramming" of the genome, thereby potentially resulting in transgenerational effects. Stem cells can also be targets of environmental stressors, thus paving another way for effects that may last a lifetime. Current testing paradigms do not allow proper characterization of risk factors and their interactions. Thus, relevant exposure levels and combinations for testing must be identified from human exposure situations and outcome assessments. Testing of potential underpinning mechanisms and biomarker development require laboratory animal models and in vitro approaches. Only few large-scale birth cohorts exist, and collaboration between birth cohorts on a global scale should be facilitated. DOHaD-based research has a crucial role in establishing factors leading to detrimental outcomes and developing early preventative/remediation strategies to combat these risks.

引用

页码：3408 / 3415

页数：8

共 31 条

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