Using the Box-Behnken experimental design to optimise operating parameters in pulsed spray fluidised bed granulation

被引：40

作者：

Liu, Huolong ^{[1
]}

Wang, Ke ^{[1
]}

Schlindwein, Walkiria ^{[1
]}

Li, Mingzhong ^{[1
]}

机构：

[1] De Montfort Univ, Sch Pharm, Leicester LE1 9BH, Leics, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2013年 / 448卷 / 02期

关键词：

Top-spray fluidised bed granulation; Box-Behnken design method; Hausner ratio; Operating parameters; Moisture content; PHYSICOCHEMICAL PROPERTIES; DROPLET SIZE; GROWTH; AGGLOMERATION; NUCLEATION; MECHANISMS; PARTICLES; QUALITY;

D O I：

10.1016/j.ijpharm.2013.03.057

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this work, the influence factors of pulsed frequency, binder spray rate and atomisation pressure of a top-spray fluidised bed granulation process were studied using the Box-Behnken experimental design method. Different mathematical models were developed to predict the mean size of granules, yield, relative width of granule distribution, Hausner ratio and final granule moisture content. The study has supported the theory that the granule size can be controlled through the liquid feed pulsing. However, care has to be taken when the pulsed frequency is chosen for controlling the granule size due to the nonlinear quadratic relation in the regression model. The design space of the ranges of operating parameters has been determined based on constraints of the mean size of granules and granule yield. High degree of prediction obtained from validation experiments has shown the reliability and effectiveness of using the Box-Behnken experimental design method to study a fluidised bed granulation process. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：329 / 338

页数：10

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