Genetics of Alzheimer's Disease

被引：63

作者：

Ridge, Perry G. ^{[1
]}

Ebbert, Mark T. W. ^{[1
,2
]}

Kauwe, John S. K. ^{[1
]}

机构：

[1] Brigham Young Univ, Dept Biol, Provo, UT 84602 USA

[2] ARUP Inst Clin & Expt Pathol, Salt Lake City, UT 84108 USA

来源：

BIOMED RESEARCH INTERNATIONAL | 2013年 / 2013卷

关键词：

AMYLOID PRECURSOR PROTEIN; MULTIFACTOR-DIMENSIONALITY REDUCTION; GENOME-WIDE ASSOCIATION; SINGLE NUCLEOTIDE POLYMORPHISMS; PLASMA CLUSTERIN CONCENTRATION; MITOCHONDRIAL-DNA HAPLOGROUPS; CLATHRIN ASSEMBLY PROTEIN; HIGH-ORDER INTERACTIONS; COMPLEMENT RECEPTOR 1; APOLIPOPROTEIN-E;

D O I：

10.1155/2013/254954

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Alzheimer's disease is the most common form of dementia and is the only top 10 cause of death in the United States that lacks disease-altering treatments. It is a complex disorder with environmental and genetic components. There are two major types of Alzheimer's disease, early onset and the more common late onset. The genetics of early-onset Alzheimer's disease are largely understood with variants in three different genes leading to disease. In contrast, while several common alleles associated with late-onset Alzheimer's disease, including APOE, have been identified using association studies, the genetics of late-onset Alzheimer's disease are not fully understood. Here we review the known genetics of early- and late-onset Alzheimer's disease.

引用

页数：13

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