Genetics of Alzheimer's Disease

被引:63
作者
Ridge, Perry G. [1 ]
Ebbert, Mark T. W. [1 ,2 ]
Kauwe, John S. K. [1 ]
机构
[1] Brigham Young Univ, Dept Biol, Provo, UT 84602 USA
[2] ARUP Inst Clin & Expt Pathol, Salt Lake City, UT 84108 USA
关键词
AMYLOID PRECURSOR PROTEIN; MULTIFACTOR-DIMENSIONALITY REDUCTION; GENOME-WIDE ASSOCIATION; SINGLE NUCLEOTIDE POLYMORPHISMS; PLASMA CLUSTERIN CONCENTRATION; MITOCHONDRIAL-DNA HAPLOGROUPS; CLATHRIN ASSEMBLY PROTEIN; HIGH-ORDER INTERACTIONS; COMPLEMENT RECEPTOR 1; APOLIPOPROTEIN-E;
D O I
10.1155/2013/254954
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Alzheimer's disease is the most common form of dementia and is the only top 10 cause of death in the United States that lacks disease-altering treatments. It is a complex disorder with environmental and genetic components. There are two major types of Alzheimer's disease, early onset and the more common late onset. The genetics of early-onset Alzheimer's disease are largely understood with variants in three different genes leading to disease. In contrast, while several common alleles associated with late-onset Alzheimer's disease, including APOE, have been identified using association studies, the genetics of late-onset Alzheimer's disease are not fully understood. Here we review the known genetics of early- and late-onset Alzheimer's disease.
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页数:13
相关论文
共 193 条
[1]   Impact of SORL1 Single Nucleotide Polymorphisms on Alzheimer's Disease Cerebrospinal Fluid Markers [J].
Alexopoulos, Panagiotis ;
Guo, Liang-Hao ;
Kratzer, Martina ;
Westerteicher, Christine ;
Kurz, Alexander ;
Perneczky, Robert .
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2011, 32 (03) :164-170
[2]   Smoking as a risk factor for Alzheimer's disease: contrasting evidence from a systematic review of case-control and cohort studies [J].
Almeida, OP ;
Hulse, GK ;
Lawrence, D ;
Flicker, L .
ADDICTION, 2002, 97 (01) :15-28
[3]   Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease [J].
Anandatheerthavarada, Hindupur K. ;
Devi, Latha .
NEUROSCIENTIST, 2007, 13 (06) :626-638
[4]   Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility [J].
Andrew, AS ;
Nelson, HH ;
Kelsey, KT ;
Moore, JH ;
Meng, AC ;
Casella, DP ;
Tosteson, TD ;
Schned, AR ;
Karagas, MR .
CARCINOGENESIS, 2006, 27 (05) :1030-1037
[5]   Rethinking Alzheimer's Disease Therapy: Are Mitochondria the Key? [J].
Ankarcrona, Maria ;
Mangialasche, Francesca ;
Winblad, Bengt .
JOURNAL OF ALZHEIMERS DISEASE, 2010, 20 :S579-S590
[6]  
[Anonymous], 2013, ALZHEIMERS DEMENTIA
[7]  
[Anonymous], 2000, AM J PATHOL
[8]  
[Anonymous], 1994, NAT MED
[9]  
Armstrong R A, 2011, Int J Alzheimers Dis, V2011, P630865, DOI 10.4061/2011/630865
[10]   Complement mediators in ischemia-reperfusion injury [J].
Arumugam, Thiruma V. ;
Magnus, Tim ;
Woodruff, Trent M. ;
Proctor, Lavinia M. ;
Shiels, Ian A. ;
Taylor, Stephen M. .
CLINICA CHIMICA ACTA, 2006, 374 (1-2) :33-45