Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation

被引:11
作者
Brestoff, Jonathan R. [3 ]
Vessoni, Alexandre T. [2 ]
Brenner, Kirsten A. [2 ]
Uy, Geoffrey L. [4 ]
DiPersio, John F. [4 ]
Blinder, Morey [2 ]
Witt, Chad A. [1 ]
Byers, Derek E. [1 ]
Hachem, Ramsey R. [1 ]
Truclock, Elbert P. [1 ]
Early, Dayna S. [5 ]
Anadkat, Milan J. [6 ]
Musiek, Amy [6 ]
Javidan-Nejad, Cylen [7 ]
Balfe, Dennis M. [7 ]
Rosman, Ilana S. [6 ,8 ]
Liu, Chang [3 ]
Zhang, Lingxin [8 ]
Despotis, George J. [9 ]
Ruzinova, Marianna B. [8 ]
Sehn, Jennifer K.
Amarillo, Ina [3 ]
Heusel, Jonathan W. [3 ]
Swat, Wojcieh [3 ]
Kim, Brian S. [6 ,9 ,10 ,11 ]
Wartman, Lukas D. [4 ]
Yusen, Roger D. [1 ,12 ,13 ]
Batista, Luis F. Z. [2 ,14 ,15 ]
机构
[1] Washington Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Div Hematol, Dept Med, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Pathol & Immunol, Div Lab & Genom Med, St Louis, MO USA
[4] Washington Univ, Sch Med, Dept Med, Div Oncol, St Louis, MO USA
[5] Washington Univ, Sch Med, Dept Med, Div Gastroenterol, St Louis, MO USA
[6] Washington Univ, Sch Med, Dept Med, Div Dermatol, St Louis, MO 63110 USA
[7] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO USA
[8] Washington Univ, Sch Med, Dept Pathol & Immunol, Div Anat & Mol Pathol, St Louis, MO USA
[9] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO USA
[10] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA
[11] Washington Univ, Sch Med, Ctr Study Itch, St Louis, MO USA
[12] Washington Univ, Sch Med, Dept Med, Div Gen Med Sci, St Louis, MO USA
[13] Washington Univ, Sch Med, Dept Med, Div Gen Med Educ, St Louis, MO USA
[14] Washington Univ, Dept Dev Biol, St Louis, MO USA
[15] Washington Univ, Ctr Regenerat Med, St Louis, MO USA
关键词
SOLID-ORGAN;
D O I
10.1136/thoraxjnl-2017-211121
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase reverse transcriptase (TERT) and short telomeres. Interstitial lung diseases have become the leading indication for lung transplantation in the USA, and recent data indicate that pathogenic mutations in telomerase may cause unfavourable outcomes following lung transplantation. Although a rare occurrence, solid organ transplant recipients who develop acute graft-versus-host disease (GVHD) have very poor survival. This case report describes the detection of a novel mutation in TERT in a patient who had lung transplantation for familial pulmonary fibrosis and died from complications of acute GVHD.
引用
收藏
页码:489 / 492
页数:4
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