An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

被引：7

作者：

Thibodeaux, Gabrielle N.

van der Donk, Wilfred A. ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 86期

基金：

美国国家卫生研究院;

关键词：

PROTEIN-KINASE; SOLID-PHASE; PHOSPHOPROTEOMICS; LACTICIN-481; SEQUENCE; MOTIFS; CANCER;

D O I：

10.1039/c2cc34138g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phosphorylation is an abundant post-translational modification involved in a myriad of cell signaling pathways. Herein, we have engineered the class II lantipeptide synthetase ProcM to generate a variety of peptides containing O-phosphoserine (pSer) and O-phosphothreonine (pThr) residues, either in vitro or in vivo.

引用

收藏

页码：10615 / 10617

页数：3

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