Cancer-associated retinopathy during treatment for small-cell lung carcinoma

被引：16

作者：

Kashiwabara, K ^{[1
]}

Nakamura, H ^{[1
]}

Kishi, K ^{[1
]}

Yagyu, H ^{[1
]}

Sarashina, G ^{[1
]}

Kobayashi, K ^{[1
]}

Matsuoka, T ^{[1
]}

机构：

[1] Taragi Municipal Hosp, Resp Dept, Taragi, Kumamoto 8680501, Japan

来源：

INTERNAL MEDICINE | 1999年 / 38卷 / 07期

关键词：

visual loss; paraneoplastic syndrome; retinal degeneration; cancer-associated retinopathy (CAR) antigen; recoverin; prednisolone;

D O I：

10.2169/internalmedicine.38.597

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 70-year-old woman with small-cell lung carcinoma (c-T4N2M0) was treated by six courses of combination chemotherapy (carboplatin and etoposide), After two weeks, she complained of a sense of darkness and night blindness. A Western blot analysis showed that the patient's serum bound with the recombinant 23-kDa retinal cancer-associated retinopathy (CAR) antigen at 1:1,000 dilution. Her visual acuity became so poor that she could only recognise a hand motion at 50 cm despite treatment with corticosteroids and combination chemotherapy. The patient was diagnosed as having a rare type of CAR because CAR is usually found before the diagnosis of primary cancer.

引用

页码：597 / 601

页数：5