Photoredox Activation for the Direct β-Arylation of Ketones and Aldehydes

被引：462

作者：

Pirnot, Michael T. ^{[1
]}

Rankic, Danica A. ^{[1
]}

Martin, David B. C. ^{[1
]}

MacMillan, David W. C. ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem, Merck Ctr Catalysis, Princeton, NJ 08544 USA

来源：

SCIENCE | 2013年 / 339卷 / 6127期

关键词：

COORDINATION-COMPOUNDS; FUNCTIONALIZATION; 1,4-ADDITION;

D O I：

10.1126/science.1232993

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The direct beta-activation of saturated aldehydes and ketones has long been an elusive transformation. We found that photoredox catalysis in combination with organocatalysis can lead to the transient generation of 5 pi-electron beta-enaminyl radicals from ketones and aldehydes that rapidly couple with cyano-substituted aryl rings at the carbonyl beta-position. This mode of activation is suitable for a broad range of carbonyl beta-functionalization reactions and is amenable to enantioselective catalysis.

引用

页码：1593 / 1596

页数：5

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