Synthesis of 4-arylcoumarins via palladium-catalyzed arylation/cyclization of ortho-hydroxylcinnamates with diaryliodonium salts

被引：16

作者：

Yang, Yang ^{[1
,2
]}

Han, Jianwei ^{[3
]}

Wu, Xunshen ^{[1
,2
]}

Xu, Shujia ^{[1
,2
]}

Wang, Limin ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 24期

关键词：

Arylation; Palladium; Cyclization; Diaryliodonium salts; Coumarin; HYPERVALENT IODINE REAGENTS; COUMARIN DERIVATIVES; BIS-ARYLATIONS; RAPID ACCESS; O-ARYLATION; HECK; ARYL; INHIBITOR;

D O I：

10.1016/j.tetlet.2015.04.082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed arylation/cyclization of ortho-hydroxylcinnamate ester derivatives by using diaryliodonium(III) salts has been developed. With this method, 4-arylcoumarins were easily prepared in good to excellent yields under base-free conditions. Additionally, this protocol provided an efficient alternative for the preparation of related 4-arylated coumarin compounds which are useful in the access to 5-lipoxygenase inhibitors. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：3809 / 3812

页数：4

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