PLA/β-TCP Complex Tubes: The Mechanical Properties and Applications of Artificial Bone

被引：14

作者：

Lou, Ching-Wen ^{[2
]}

Yao, Chun-Hsu ^{[3
]}

Chen, Yueh-Sheng ^{[3
]}

Lu, Chao-Tsang ^{[4
]}

Chen, Wen-Cheng ^{[5
]}

Yen, Ke-Chung ^{[1
]}

Lin, Jia-Horng ^{[1
,6
]}

机构：

[1] Feng Chia Univ, Lab Fiber Applicat & Mfg, Dept Fiber & Composite & Mat, Taichung 40724, Taiwan

[2] Cent Taiwan Univ Sci & Technol, Inst Biomed Engn & Mat Sci, Taichung 40601, Taiwan

[3] China Med Univ, Dept Biomed Imaging & Radiol Sci, Taichung 40402, Taiwan

[4] Cent Taiwan Univ Sci & Technol, Inst Life Sci, Taichung 40601, Taiwan

[5] Feng Chia Univ, Dept Fiber & Composite Mat, Adv Med Devices & Composite Lab, Taichung 407, Taiwan

[6] China Med Univ, Sch Chinese Med, Taichung 40402, Taiwan

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2012年 / 23卷 / 13期

关键词：

beta-TCP; poly(lactic acid); complex tubes; MG-63; 16-spindle braid machine;

D O I：

10.1163/092050611X597762

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poly(lactic acid) (PLA) twisted yarn was braided into a 6-layered, hollow, cylindrical braid on a 16-spindle braid machine. The PLA braid was then placed inside a beta-TCP tube, forming the PLA/beta-TCP complex tube which imitates the porous structure of sponge bone. Different components and structures were studied to determine the best bone molding material. The beta-TCP tube was created by sintering TCP powder mixed with stearic acid in a ratio of 1:1.5 to form a highly porous and well-structured tube with interconnected pores; its resulting porosity was 85.8 +/- 0.93%. The PLA/beta-TCP complex tube was implanted in a rabbit's femur and after 3 months a marrow cavity was discovered at the tube's core. New bone was also observed, regenerating around the PLA braid within the PLA/beta-TCP complex tube. (C) Koninklijke Brill NV, Leiden, 2011

引用

页码：1701 / 1712

页数：12

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