PLA/β-TCP Complex Tubes: The Mechanical Properties and Applications of Artificial Bone

被引:14
|
作者
Lou, Ching-Wen [2 ]
Yao, Chun-Hsu [3 ]
Chen, Yueh-Sheng [3 ]
Lu, Chao-Tsang [4 ]
Chen, Wen-Cheng [5 ]
Yen, Ke-Chung [1 ]
Lin, Jia-Horng [1 ,6 ]
机构
[1] Feng Chia Univ, Lab Fiber Applicat & Mfg, Dept Fiber & Composite & Mat, Taichung 40724, Taiwan
[2] Cent Taiwan Univ Sci & Technol, Inst Biomed Engn & Mat Sci, Taichung 40601, Taiwan
[3] China Med Univ, Dept Biomed Imaging & Radiol Sci, Taichung 40402, Taiwan
[4] Cent Taiwan Univ Sci & Technol, Inst Life Sci, Taichung 40601, Taiwan
[5] Feng Chia Univ, Dept Fiber & Composite Mat, Adv Med Devices & Composite Lab, Taichung 407, Taiwan
[6] China Med Univ, Sch Chinese Med, Taichung 40402, Taiwan
关键词
beta-TCP; poly(lactic acid); complex tubes; MG-63; 16-spindle braid machine;
D O I
10.1163/092050611X597762
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Poly(lactic acid) (PLA) twisted yarn was braided into a 6-layered, hollow, cylindrical braid on a 16-spindle braid machine. The PLA braid was then placed inside a beta-TCP tube, forming the PLA/beta-TCP complex tube which imitates the porous structure of sponge bone. Different components and structures were studied to determine the best bone molding material. The beta-TCP tube was created by sintering TCP powder mixed with stearic acid in a ratio of 1:1.5 to form a highly porous and well-structured tube with interconnected pores; its resulting porosity was 85.8 +/- 0.93%. The PLA/beta-TCP complex tube was implanted in a rabbit's femur and after 3 months a marrow cavity was discovered at the tube's core. New bone was also observed, regenerating around the PLA braid within the PLA/beta-TCP complex tube. (C) Koninklijke Brill NV, Leiden, 2011
引用
收藏
页码:1701 / 1712
页数:12
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