Transfer hydrogenation of α-branched ketimines:: Enantioselective synthesis of cycloalkylamines via dynamic kinetic resolution

被引：51

作者：

Ros, A

Magriz, A

Dietrich, H

Ford, M

Fernández, R

Lassaletta, JM

机构：

[1] USe, CSIC, Inst Invest Quim, Seville 41092, Spain

[2] Bayer CropSci GmbH, D-65926 Frankfurt, Germany

[3] Univ Sevilla, Dept Quim Organ, Seville 41071, Spain

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2005年 / 347卷 / 15期

关键词：

amines; asymmetric catalysis; dynamic kinetic resolution; iridium; ruthenium; transfer hydrogenation;

D O I：

10.1002/adsc.200505291

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The transfer hydrogenation of 2-substituted bicyclic and monocyclic ketimines using HCO2H/ Et3N as the hydrogen source and TsDPEN-based Ru(II) and Ir(III) catalysts proceeds with dynamic kinetic resolution to afford the corresponding cis-cycloalkylamines with moderate to excellent levels of diastero- and enantioselectivity. A "one-pot" procedure starting from ketones as starting materials with in situ formation of the reacting imines has also been developed.

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页码：1917 / 1920

页数：4

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