COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature

被引：0
作者：
Di Lorenzo, Giuseppe [1 ,2 ]
Di Trolio, Rossella [3 ]
Kozlakidis, Zisis [4 ]
Busto, Giuseppina [1 ]
Ingenito, Concetta [1 ]
Buonerba, Luciana [1 ]
Ferrara, Claudia [1 ]
Libroia, Annamaria [1 ]
Ragone, Gianluca [1 ]
dello Ioio, Concetta [1 ]
Savastano, Beatrice [1 ]
Polverino, Mario [1 ]
De Falco, Ferdinando [1 ]
Iaccarino, Simona [1 ]
Leo, Emilio [1 ]
机构：
[1] Andrea Tortora Hosp, ASL Salerno, Oncol Unit, I-84016 Pagani, Italy
[2] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, I-86100 Campobasso, Italy
[3] Ist Nazl Tumori IRCCS Fdn G Pascale, Unit Melanoma Canc Immunotherapy & Dev Therapeut, Via Mariano Semmola, Naples, Italy
[4] World Hlth Org, Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon, France
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2020年 / 152卷
关键词：
Coronavirus disease SARS-CoV-2 (COVID-19); Cancer; Antiviral therapy; Management; Drug-interactions; CANCER;
D O I：
10.1016/j.critrevonc.2020.102901
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: It is reasonable to think that cancer patients undergoing chemotherapy, targeted therapy or immunotherapy could have a more aggressive course if positive for Coronavirus disease CoV-2 (COVID-19). Methods: We conducted a literature review on Raps://www.ncbi.nlm.nih.gov/pubmed/, https://scholar.google.com, www.arxiv.org, www.biorxiv.org, of all articles published using the keywords COVID-19 therapy or treatment and cancer until May 2, 2020. A total of 205 articles were identified and 53 were included in this review. Results: We describe the ongoing COVID-19 therapies that should be known by oncologists and highlight the potential interactions with antineoplastic drugs, commonly used in clinical practice. The main drug interactions were found with tocilizumab, ruxolitinib and colchicine. Conclusions. The literature provides an inconclusive picture on potential preferred treatments for COVID-19 and their interactions with antineoplastic agents. Future clinical trials are needed to better understand the interactions between different drugs in the context of COVID-19 pandemic.
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页数：8
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