Characterization of three small supernumerary marker chromosomes (sSMC) in humans

被引：9
作者：
Ou, Jian [1 ]
Wang, Wei [1 ]
Liehr, Thomas [2 ]
Klein, Elisabeth [2 ]
Hamid, Ahmed B. [2 ]
Wang, Fuxin [1 ]
Duan, Chengying [1 ]
Li, Hong [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Suzhou Hosp, Suzhou Municipal Hosp, Ctr Reprod & Genet, Nanjing, Jiangsu, Peoples R China
[2] Univ Jena, Jena Univ Hosp, Inst Human Genet, Jena, Germany
来源：
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2013年 / 26卷 / 01期
关键词：
Euchromatin; fluorescence in situ hybridization (FISH); heterochromatin; small supernumerary marker chromosomes (sSMC); REGION;
D O I：
10.3109/14767058.2012.732129
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
In the present study, three prenatally detected small supernumerary marker chromosomes (sSMC) were identified by banding cytogenetics and characterized in detail by molecular cytogenetics. In one case an sSMC(10) leading to a pericentric partial trisomy and in two cases heterochromatic sSMC derived from chromosome 22 were characterized. Outcomes were reportedly normal for two of the three cases for whom this information was known.
引用
收藏
页码：106 / 108
页数：3
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