Expression of PCNA and bcl-2 in basaloid squamous cell carcinoma of the larynx: A controlled study

被引：10
作者：
Deniz, Kemal [1 ]
Yuce, Imdat [2 ]
Cagli, Sedat [2 ]
Okten, Turhan [1 ]
Guney, Ercihan [2 ]
机构：
[1] Erciyes Univ, Dept Pathol, Fac Med, TR-38039 Kayseri, Turkey
[2] Erciyes Univ, Dept Otorhinolaryngol Head & Neck Surg, Fac Med, TR-38039 Kayseri, Turkey
来源：
ENT-EAR NOSE & THROAT JOURNAL | 2008年 / 87卷 / 08期
关键词：
D O I：
10.1177/014556130808700814
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
We investigated the difference In the biologic nature of typical squamous cell Carcinoma (SCC) and basaloid SCC (BSCC) of the larynx by studying proliferation and antiapoptotic markers. We performed an immunohistochemical analysis of the expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 15 patients with laryngeal BSCC and 15 stage- and site-matched controls with typical laryngeal SCC. We found no significant difference between the two groups in the PCNA index or the frequency of bcl-2 overexpression, nor did we find and significant difference in survival. Our findings Indicate that the biologic nature of typical laryngeal SCC and laryngeal BSCC is similar. In addition, our follow-up data suggest that the clinical course of laryngeal BSCC is no worse than that of typical laryngeal SCC.
引用
收藏
页码：469 / 473
页数：5
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