Expression of PCNA and bcl-2 in basaloid squamous cell carcinoma of the larynx: A controlled study

被引：10
|
作者：
Deniz, Kemal [1 ]
Yuce, Imdat [2 ]
Cagli, Sedat [2 ]
Okten, Turhan [1 ]
Guney, Ercihan [2 ]
机构：
[1] Erciyes Univ, Dept Pathol, Fac Med, TR-38039 Kayseri, Turkey
[2] Erciyes Univ, Dept Otorhinolaryngol Head & Neck Surg, Fac Med, TR-38039 Kayseri, Turkey
来源：
ENT-EAR NOSE & THROAT JOURNAL | 2008年 / 87卷 / 08期
关键词：
D O I：
10.1177/014556130808700814
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
We investigated the difference In the biologic nature of typical squamous cell Carcinoma (SCC) and basaloid SCC (BSCC) of the larynx by studying proliferation and antiapoptotic markers. We performed an immunohistochemical analysis of the expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 15 patients with laryngeal BSCC and 15 stage- and site-matched controls with typical laryngeal SCC. We found no significant difference between the two groups in the PCNA index or the frequency of bcl-2 overexpression, nor did we find and significant difference in survival. Our findings Indicate that the biologic nature of typical laryngeal SCC and laryngeal BSCC is similar. In addition, our follow-up data suggest that the clinical course of laryngeal BSCC is no worse than that of typical laryngeal SCC.
引用
收藏
页码：469 / 473
页数：5
相关论文
共 50 条
  • [1] Immunohistochemical expression of bcl-2 protein in squamous cell carcinoma and basaloid carcinoma of the esophagus
    Naohiko Koide
    Shoichiro Koike
    Wataru Adachi
    Jun Amano
    Nobuteru Usuda
    Tetsuji Nagata
    Surgery Today, 1997, 27 : 685 - 691
  • [2] Immunohistochemical expression of bcl-2 protein in squamous cell carcinoma and basaloid carcinoma of the esophagus
    Koide, N
    Koike, S
    Adachi, W
    Amano, J
    Usuda, N
    Nagata, T
    SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 1997, 27 (08): : 685 - 691
  • [3] Prognostic value of Bcl-2 expression in squamous cell carcinoma of the larynx: a systematic review
    Gioacchini, Federico Maria
    Alicandri-Ciufelli, Matteo
    Rubini, Corrado
    Magliulo, Giuseppe
    Re, Massimo
    INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 2015, 30 (02): : E155 - E160
  • [4] C-myc and bcl-2 expression in supraglottic squamous cell carcinoma of the larynx
    Ozdek, A
    Sarac, S
    Akyol, ML
    Sungur, A
    Yilmaz, T
    OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2004, 131 (01) : 77 - 83
  • [5] Basaloid squamous cell carcinoma - larynx
    Singhal S.K.
    Panda N.K.
    Mann S.B.S.
    Dass A.
    Indian Journal of Otolaryngology and Head & Neck Surgery, 1997, 49 (3) : 265 - 268
  • [6] Basaloid squamous cell carcinoma of the larynx
    Sheen, TS
    Chang, YL
    Ko, JY
    Wu, CT
    Lee, SY
    OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1999, 121 (05) : 647 - 650
  • [7] Basaloid squamous cell carcinoma of the larynx
    Eryilmaz, A
    Gocer, C
    Acar, A
    Dagli, M
    Albayrak, L
    JOURNAL OF LARYNGOLOGY AND OTOLOGY, 2002, 116 (01): : 52 - 53
  • [8] Basaloid squamous cell carcinoma of the larynx
    Akyol, MU
    Seckin, S
    Akbayrak, L
    Ozdem, C
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 1995, 252 (08) : 485 - 487
  • [9] Basaloid squamous cell carcinoma of the larynx
    Alkan, S
    Coskun, BU
    Ugur, S
    Basak, T
    Dadas, B
    AURIS NASUS LARYNX, 2006, 33 (01) : 71 - 74
  • [10] Overexpression of Bcl-2 in squamous cell carcinoma of the larynx: A marker of radioresistance
    Condon, LT
    Ashman, JNE
    Ell, SR
    Stafford, ND
    Greenman, J
    Cawkwell, L
    INTERNATIONAL JOURNAL OF CANCER, 2002, 100 (04) : 472 - 475
12345