Rhodium-catalyzed asymmetric transfer hydrogenation of alkyl and aryl ketones in aqueous media

被引：53

作者：

Ahlford, Katrin ^{[1
]}

Lind, Jesper ^{[2
]}

Maler, Lena ^{[2
]}

Adolfsson, Hans ^{[1
]}

机构：

[1] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden

[2] Stockholm Univ, Arrhenius Lab, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden

来源：

GREEN CHEMISTRY | 2008年 / 10卷 / 08期

关键词：

D O I：

10.1039/b806177g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel lipophilic rhodium catalyst was evaluated in the enantioselective transfer hydrogenation of ketones in water using sodium formate as the hydride donor, and in the presence of sodium docecylsulfonate. Alkyl alkyl ketones were reduced in good yields and in moderate to good enantioselectivities, and the reduction of aryl alkyl ketones proceeded with excellent enantioselectivity (up to 97% ee).

引用

页码：832 / 835

页数：4

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