Frequency of sister chromatid exchange in chrysotile-exposed workers

被引：6
作者：
Lee, SH
Shin, M
Lee, KJ
Lee, SY
Lee, JT
Lee, YH
机构：
[1] Catholic Univ Korea, Coll Med, Dept Prevent Med, Seoul 137701, South Korea
[2] Inye Univ, Coll Med, Dept Prevent Med, Pusan, South Korea
[3] Kosin Univ, Coll Med, Dept Prevent Med, Pusan, South Korea
来源：
TOXICOLOGY LETTERS | 1999年 / 108卷 / 2-3期
关键词：
chrysotile; SCE; smoking; confounder;
D O I：
10.1016/S0378-4274(99)00104-6
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Chrysotile, which is an industrial carcinogen, has been shown to induce a dose-dependent increase in the frequency of sister chromatid exchange (SCE) in vitro. Authors designed this study to examine the increase of SCEs frequency in the workers occupationally exposed to chrysotile. Heparinized whole blood samples from 45 chrysotile-exposed and 45 control volunteers were cultured for 72 h. The significant difference of SCE frequency was found between chrysotile-exposed workers and control group. The highest SCEs frequency was found in chrysotile-exposed smokers, and the lowest in control non-smokers. The effect of chrysotile exposure on SCEs was marginally significant after controlling the effects of age and smoking by multiple regression analysis. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：315 / 319
页数：5
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