Ni-Catalyzed Synthesis of Fluoroarenes via [2+2+2] Cycloaddition Involving -Fluorine Elimination

被引：22

作者：

Fujita, Takeshi ^{[1
]}

Watabe, Yota ^{[1
]}

Ichitsuka, Tomohiro ^{[1
]}

Ichikawa, Junji ^{[1
]}

机构：

[1] Univ Tsukuba, Fac Pure & Appl Sci, Div Chem, Tsukuba, Ibaraki 3058571, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 38期

关键词：

alkynes; CF bond activation; fluoroalkenes; fluoroarenes; nickel; DIFLUORO-SUBSTITUTED 1,6-ENYNES; F BOND ACTIVATION; ARYL FLUORIDES; COUPLING REACTIONS; VINYLIC FLUORINES; LATE-STAGE; ALKYNES; CYCLIZATION; PALLADIUM; ARYNES;

D O I：

10.1002/chem.201502744

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for direct synthesis of tetrasubstituted fluoroarenes via nickel-catalyzed [2+2+2] cycloaddition is presented. The reaction combines one molecule of 1,1-difluoroethylene with two molecules of alkynes and involves sequential cleavage of the CF and CH bonds in difluoroethylene. The catalytic cycle is established by reduction of the intermediary Ni-II fluoride with a triethylborane-based borate.

引用

页码：13225 / 13228

页数：4

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