Genetic Expression Profile During Acute Cellular Rejection in Clinical Intestinal Transplantation

被引：12

作者：

Bradley, Sean P. ^{[1
]}

Banner, Barbara ^{[2
]}

Elias, George ^{[1
]}

Pahari, Mohan P. ^{[1
]}

Brown, Melissa ^{[1
]}

Rastellini, Cristiana ^{[1
]}

Cicalese, Luca ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Surg, Div Organ Transplantat, UMass Mem HealthCare,Med Sch, Worcester, MA 01605 USA

[2] Univ Massachusetts, Dept Pathol, Sch Med, UMass Mem HealthCare, Worcester, MA 01605 USA

来源：

TRANSPLANTATION | 2008年 / 86卷 / 07期

关键词：

Intestinal transplant; Acute cellular rejection; Gene expression; Type I interferon; Dendritic cells;

D O I：

10.1097/TP.0b013e3181874989

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Small bowel transplantation is a successful treatment for irreversible intestinal failure. Acute cellular rejection (ACR) represents the major cause of graft loss. However, little is known regarding the mechanisms of ACR and no data exist on the genetic response occurring during ACR. We report a genetic expression profile determined using oligo-microarrays of the intestinal graft during an ACR episode. Mucosal biopsies were obtained from the graft at weeks 0, 1, 2, 3, 6, and 52 posttransplant. We observed a statistically significant increase in transcript levels from 51 genes between biopsy samples from before ACR compared with during ACR. Functional analysis of these genes revealed an interferon (IFN)-alpha signature associated with a type 1 IFN immune response from dendritic cells or association with cellular proliferation and division. These genetic data support that dendritic cell activation was ongoing during ACR and suggest that IFN alpha production as a potential immunosuppressive target for transplantation.

引用

页码：998 / 1001

页数：4

共 31 条

[1] Plasmacytoid dendritic cells: In vivo regulators of alloimmune reactivity? [J].