Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

被引：161
作者：
Espinoza, Ingrid [1 ,2 ]
Pochampally, Radhika [1 ,2 ]
Xing, Fei [1 ]
Watabe, Kounosuke [1 ,3 ]
Miele, Lucio [1 ,4 ]
机构：
[1] Univ Mississippi, Inst Canc, Med Ctr, Jackson, MS 39216 USA
[2] Univ Mississippi, Dept Biochem, Med Ctr, Jackson, MS 39216 USA
[3] Univ Mississippi, Dept Microbiol, Med Ctr, Jackson, MS 39216 USA
[4] Univ Mississippi, Dept Pharmacol & Toxicol, Med Ctr, Jackson, MS 39216 USA
来源：
ONCOTARGETS AND THERAPY | 2013年 / 6卷
关键词：
Notch signaling; EMT; cancer stem cells; mesenchymal stem cells; metastases; Notch inhibitors; SECRETASE INHIBITOR PF-03084014; MARROW STROMAL CELLS; TUMOR MICROENVIRONMENT; SELF-RENEWAL; PROSTATE-CANCER; DOWN-REGULATION; GROWTH; EXPRESSION; ACTIVATION; LIGAND;
D O I：
10.2147/OTT.S36162
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EMT) have been reported. This review describes the role of Notch in the "stemness" program in cancer cells and in metastases, together with a brief update on the Notch inhibitors currently under investigation in oncology. These agents may be useful in targeting cancer stem cells and to reverse the EMT process.
引用
收藏
页码：1249 / 1259
页数：11
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