Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

被引：161

作者：

Espinoza, Ingrid ^{[1
,2
]}

Pochampally, Radhika ^{[1
,2
]}

Xing, Fei ^{[1
]}

Watabe, Kounosuke ^{[1
,3
]}

Miele, Lucio ^{[1
,4
]}

机构：

[1] Univ Mississippi, Inst Canc, Med Ctr, Jackson, MS 39216 USA

[2] Univ Mississippi, Dept Biochem, Med Ctr, Jackson, MS 39216 USA

[3] Univ Mississippi, Dept Microbiol, Med Ctr, Jackson, MS 39216 USA

[4] Univ Mississippi, Dept Pharmacol & Toxicol, Med Ctr, Jackson, MS 39216 USA

来源：

ONCOTARGETS AND THERAPY | 2013年 / 6卷

关键词：

Notch signaling; EMT; cancer stem cells; mesenchymal stem cells; metastases; Notch inhibitors; SECRETASE INHIBITOR PF-03084014; MARROW STROMAL CELLS; TUMOR MICROENVIRONMENT; SELF-RENEWAL; PROSTATE-CANCER; DOWN-REGULATION; GROWTH; EXPRESSION; ACTIVATION; LIGAND;

D O I：

10.2147/OTT.S36162

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EMT) have been reported. This review describes the role of Notch in the "stemness" program in cancer cells and in metastases, together with a brief update on the Notch inhibitors currently under investigation in oncology. These agents may be useful in targeting cancer stem cells and to reverse the EMT process.

引用

页码：1249 / 1259

页数：11

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