Bioactive diterpenoids isolated from Salvia mellifera

被引：0

作者：

Moujir, L ^{[1
]}

GutierrezNavarro, AM ^{[1
]}

Andres, LS ^{[1
]}

Luis, JG ^{[1
]}

机构：

[1] UNIV LA LAGUNA, INST UNIV BIOORGAN, CPNO, E-38206 San Cristobal la Laguna, TENERIFE, SPAIN

来源：

PHYTOTHERAPY RESEARCH | 1996年 / 10卷 / 02期

关键词：

Lamiaceae; Salvia; diterpenoids; abietanes; antimicrobial activity; cytotoxicity;

D O I：

10.1002/(SICI)1099-1573(199603)10:2<172::AID-PTR797>3.3.CO;2-H

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight diterpenoids were isolated from the roots of Salvia mellifera Greene, Their structures were elucidated by comparison to their physical and spectroscopy data with those reported in the literature or that of authentic samples as: abieta-8,11,13-triene, ferruginol, 15-deoxi-fuerstione, taxodione, isotanishinone III, rolyeanone, 7 alpha-hydroxi-rolyleanone and demethylsalvicanol, Demethylsalvican-11-12-dione was obtained by oxidation with Ag2O from demethylsalvicanol, Compounds ferruginol, taxodione, isotanshinone III, and 7 alpha-hydroxi-royleanone showed cytotoxic activity against both HeLa and Hep-2 cells in culture, Royleanone and demethylsalvican-11-12-dione were active on Hep-2 and HeLa cells respectively, Antimicrobial activity against some Gram (+) bacteria was observed for the diterpenoids ferruginol, taxodione, 7 alpha-hydroxi-royleanone and demethylsalvican-11-12-dione. None of them was active on Gram (-) bacteria or Candida albicans.

引用

页码：172 / 174

页数：3

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