The Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas receptor axis: A potential target for treating thrombotic diseases

被引：50

作者：

Fraga-Silva, Rodrigo A. ^{[4
]}

Da Silva, Danielle G. ^{[4
]}

Montecucco, Fabrizio ^{[2
,3
]}

Mach, Francois ^{[3
]}

Stergiopulos, Nikolaos ^{[4
]}

da Silva, Rafaela F. ^{[1
,4
]}

Santos, Robson A. S. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Physiol & Biophys, Inst Biol Sci, Natl Inst Sci & Technol Nanobiopharmaceut, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Genoa, Dept Internal Med, Clin Internal Med 1, I-16126 Genoa, Italy

[3] Univ Hosp Geneva, Fac Med, Fdn Med Res, Div Cardiol, Geneva, Switzerland

[4] Ecole Polytech Fed Lausanne, Inst Bioengn, Lausanne, Switzerland

来源：

THROMBOSIS AND HAEMOSTASIS | 2012年 / 108卷 / 06期

关键词：

Angiotensin-(1-7); Angiotensin Converting Enzyme 2; Receptor Mas; thrombosis; platelet; TISSUE-PLASMINOGEN ACTIVATOR; RENIN-ANGIOTENSIN; ENDOTHELIAL DYSFUNCTION; PLATELET AGGREGABILITY; PROTHROMBOTIC STATE; T-LYMPHOCYTES; SYSTEM; INHIBITION; HYPERTENSION; BLOCKADE;

D O I：

10.1160/TH12-06-0396

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidity and mortality. Remarkable effort has been made to identify new drug targets. There is growing evidence indicating that the recently described counter-regulator axis of the renin-angiotensin system (RAS), composed of Angiotensin-Converting Enzyme 2 (ACE2), Angiotensin-(1-7) and the Mas receptor, has protective effects against thrombosis. In addition, it could be considered as a promising target for treating or preventing this disease. In this narrative review, we focused on the recent findings of the role of the ACE2/Angiotensin-(1-7)/Mas axis on the haemostatic process and its therapeutic potential.

引用

页码：1089 / 1096

页数：8

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