Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice

被引：9

作者：

Gong, Fayong ^{[1
]}

Li, Fenglin ^{[2
,3
]}

Zhang, Wanming ^{[1
]}

Li, Jing ^{[1
]}

Zhang, Zhong ^{[1
]}

机构：

[1] Xichang Coll, Sch Appl & Chem Engn, Xichang 615000, Sichuan Provinc, Peoples R China

[2] Yanshan Univ, Coll Mat Sci & Engn, Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066400, Hebei Province, Peoples R China

[3] Jilin Agr Sci & Technol, Dept Bioengn, Jilin 132101, Jilin Province, Peoples R China

来源：

BANGLADESH JOURNAL OF PHARMACOLOGY | 2012年 / 7卷 / 02期

关键词：

Flavonoid; Diabetes mellitus; Oxidative stress; Tatary buckwheat; PANCREATIC BETA-CELLS; INDUCED DIABETIC-RATS; TARTARY BUCKWHEAT; ANTIOXIDANT ACTIVITY; COMPLICATIONS; INSULIN; POLYSACCHARIDES; HYPERGLYCEMIA; METABOLISM; EXTRACTION;

D O I：

10.3329/bjp.v7i2.10993

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was undertaken to evaluate the effects of crude flavonoids from tatary buckwheat (FTB) on alloxan-induced oxidative stress in mice. After induction of diabetes, diabetic mice were randomly divided into four groups: one diabetic control group and three different doses of FTB (100, 200 and 400 mg/kg) treated groups, with non-diabetic mice used as the normal control group. The mice were intragastrically administered once daily for 28 days. Fasting blood glucose (FBG), serum insulin, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and malondialdehyde (MDA) were measured. The results showed that FTB could significantly reduce FBG levels and MDA contents, and increase serum insulin levels, SOD, GPx and CAT activities. These data suggested that FTB possess hypoglycemic effects and could reduce alloxan-induced oxidative stress in mice. Therefore, FTB might be of use as an antidiabetic drug.

引用

页码：124 / 130

页数：7

共 29 条

[1]

Aronson D, 2008, ADV CARDIOL, V45, P1, DOI 10.1159/000115118

[2]

Bicu Mihaela, 2010, Rom J Intern Med, V48, P307

[3] Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids [J].

Bikopoulos, George ;

Pimenta, Aurelio Da Silva ;

Lee, Simon C. ;

Lakey, Jonathan R. ;

Der, Sandy D. ;

Chan, Catherine B. ;

Ceddia, Rolando Bacis ;

Wheeler, Michael B. ;

Rozakis-Adcock, Maria .

JOURNAL OF ENDOCRINOLOGY, 2008, 196 (03) :455-464

[4] Extraction, purification, characterization and hypoglycemic activity of a polysaccharide isolated from the root of Ophiopogon japonicus [J].

Chen, Xiaoming ;

Jin, Jing ;

Tang, Jia ;

Wang, Zhongfu ;

Wang, Junjun ;

Jin, Liqin ;

Lu, Jianxin .

CARBOHYDRATE POLYMERS, 2011, 83 (02) :749-754

[5] Protective effects of polyphenolics in red wine on diabetes associated oxidative/nitrative stress in streptozotocin-diabetic rats [J].

Drel, Viktor R. ;

Sybirna, Nataliya .

CELL BIOLOGY INTERNATIONAL, 2010, 34 (12) :1147-1153

[6]

EGAN JM, 1991, P SOC EXP BIOL MED, V196, P203

[7] Tartary buckwheat (Fagopyrum tataricum Gaertn.) as a source of dietary rutin and quercitrin [J].

Fabjan, N ;

Rode, J ;

Kosir, IJ ;

Wang, ZH ;

Zhang, Z ;

Kreft, I .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (22) :6452-6455

[8] Hypoglycemic Effects of Crude Polysaccharide from Purslane [J].

Gong, Fayong ;

Li, Fenglin ;

Zhang, Lili ;

Li, Jing ;

Zhang, Zhong ;

Wang, Guangyao .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2009, 10 (03) :880-888

[9] Anti-hyperglycemic effect of Eugenia jambolana and Tinaspora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism [J].

Grover, JK ;

Vats, V ;

Rathi, SS .

JOURNAL OF ETHNOPHARMACOLOGY, 2000, 73 (03) :461-470

[10] Phenolics Content and Antioxidant Activity of Tartary Buckwheat from Different Locations [J].

Guo, Xu-Dan ;

Ma, Yu-Jie ;

Parry, John ;

Gao, Jin-Ming ;

Yu, Liang-Li ;

Wang, Min .

MOLECULES, 2011, 16 (12) :9850-9867

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