Population-Attributable Risks for Ischemic Stroke in a Community in South Brazil: A Case-Control Study

被引:18
作者
Mallmann, Adroaldo Baseggio [1 ]
Fuchs, Sandra Costa [2 ]
Gus, Miguel [3 ]
Fuchs, Flavio Danni [3 ]
Moreira, Leila Beltrami [2 ]
机构
[1] Univ Passo Fundo, Sch Med, Passo Fundo, Brazil
[2] Univ Fed Rio Grande do Sul, Postgrad Program Cardiol, Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Cardiol, Porto Alegre, RS, Brazil
来源
PLOS ONE | 2012年 / 7卷 / 04期
关键词
CAROTID BRUITS; MORTALITY; ASSOCIATION; CARDIOLOGY; LIFE; CHOLESTEROL; PREVENTION; ADULTS;
D O I
10.1371/journal.pone.0035680
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Risk factors for ischemic stroke are mostly known, but it is still unclear in most countries, what are their combined population-attributable risk percent (PAR%). In a case-control study the individual odds ratios (ORs) and the individual and combined PAR%, including risk factors not addressed in previous studies were estimated. Methods: Cases and controls were selected from patients attending to an emergency department. Cases were patients aged with 45 years or more with the first episode of ischemic stroke, characterized by a focal neurological deficit or change in the mental status occurring during the previous 24 hours. Controls, matched to cases by age and gender, were selected from patients without neurological complaints. Results: 133 cases and 272 controls were studied. Odds ratios for ischemic stroke were: atrial fibrillation (27.3; CI 95% 7.5-99.9), left ventricular hypertrophy (20.3; CI 95% 8.8-46.4), history of hypertension (11.2; CI 95% 5.4-23.3), physical inactivity (6.6; CI 95% 3.3-13.1), low levels of HDL-cholesterol (5.0; CI 95% 2.8-8.9), heavy smoking (2.8; CI 95% 1.5-5.0), carotid bruit (2.5; CI 95% 1.3-4.6), diabetes (2.4; CI 95% 1.4-4.0) and alcohol abuse (2.1; CI 95% 1.1-4.0), The combination of these risk factors accounted for 98.9% (95% CI; 96.4%-99.7%) of the PAR% for all stroke. Conclusions: Nine risk factors, easily identified, explain almost 100% of the population attributable risk for ischemic stroke.
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页数:4
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