BIGINELLI AND MANNICH MULTICOMPONENT REACTIONS IN THE UNDERGRADUATE ORGANIC CHEMISTRY LABORATORY. A DIDACTIC APPROACH TO GREEN CHEMISTRY PRINCIPLES

被引：12

作者：

Marques, Marcelo Volpatto ^{[1
]}

Bisol, Tula Beck ^{[1
]}

Sa, Marcus Mandolesi ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil

来源：

QUIMICA NOVA | 2012年 / 35卷 / 08期

关键词：

Mannich reaction; Biginelli reaction; Green Chemistry; ONE-POT SYNTHESIS; BETA-ACETAMIDO KETONES; EFFICIENT SYNTHESIS; SOLVENT; DIHYDROPYRIMIDINONES; ACID; CATALYST;

D O I：

10.1590/S0100-40422012000800034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

BIGINELLI AND MANNICH MULTICOMPONENT REACTIONS IN THE UNDERGRADUATE ORGANIC CHEMISTRY LABORATORY. A DIDACTIC APPROACH TO GREEN CHEMISTRY PRINCIPLES. The introduction of Mannich and Biginelli multicomponent reactions in a practical Organic Chemistry course is presented in this article. Procedures described in the literature were adapted for use under the simple conditions available in undergraduate laboratories and were selected on the basis of Green Chemistry principles and practicality of synthesis. The reactions are easy to carry out and all products are readily isolated as crystalline solids with yields ranging from moderate to high.

引用

页码：1696 / U254

页数：8

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