Efficacy of End-Only-Functionalized Oligo(arylene-ethynylene)s in Killing Bacterial Biofilms

被引：17

作者：

Dascier, Dimitri ^{[1
,2
]}

Ji, Eunkyung ^{[1
,2
]}

Parthasarathy, Anand ^{[3
]}

Schanze, Kirk S. ^{[3
]}

Whitten, David G. ^{[1
,2
]}

机构：

[1] Univ New Mexico, Dept Chem & Nucl Engn, Albuquerque, NM 87131 USA

[2] Univ New Mexico, Ctr Biomed Engn, Albuquerque, NM 87131 USA

[3] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

LANGMUIR | 2012年 / 28卷 / 31期

关键词：

PHENYLENE ETHYNYLENE OLIGOMERS; MEMBRANE PERTURBATION ACTIVITY; CONJUGATED POLYELECTROLYTES; BIOCIDAL ACTIVITY; POLYMERS; SUSCEPTIBILITY; ANTIBIOTICS; LIGHT; MODEL;

D O I：

10.1021/la302476s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cationic end-only-functionalized oligo(arylene-ethynylene)s (EO-OPEs) have recently been found to be broad-spectrum and effective antimicrobial agents because of their unique structure and optical properties. In this study, we investigated their potential use for preventing and reducing Escherichia coli (E. coli) biofilms. The Calgary biofilm device (CBD) was used to form bacterial biofilms of E. coli; in these studies, the minimum inhibitory concentration (MIC) and the minimum biofilm eradication concentration (MBEC) were determined. E. coli biofilms uniformly grow on pegs of the CBD device lid. The MIC values determined for EO-OPEs are comparable to those found for standard antibiotics such as kanamycin (MIC = 11.2 mu g/mL). About 10-30 times the concentration of EO-OPEs was required to eradicate E. coli biofilms and prevent regrowth in the dark. Near-UV irradiation of EO-OPEs enhanced their efficacy in killing biofilms.

引用

页码：11286 / 11290

页数：5

共 27 条

[1] Vancomycin covalently bonded to titanium alloy prevents bacterial colonization [J].

Antoci, Valentin, Jr. ;

King, Samuel B. ;

Jose, Binoy ;

Parvizi, Javad ;

Zeiger, Allen R. ;

Wickstrom, Eric ;

Freeman, Theresa A. ;

Cornposto, Russell J. ;

Ducheyne, Paul ;

Shapiro, Irving M. ;

Hickok, Noreen J. ;

Adams, Christopher S. .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2007, 25 (07) :858-866

[2] Activity of an antimicrobial peptide mimetic against planktonic and biofilm cultures of oral pathogens [J].

Beckloff, Nicholas ;

Laube, Danielle ;

Castro, Tammy ;

Furgang, David ;

Park, Steven ;

Perlin, David ;

Clements, Dylan ;

Tang, Haizhong ;

Scott, Richard W. ;

Tew, Gregory N. ;

Diamond, Gill .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (11) :4125-4132

[3]

Ben-Shabat S, 2002, ANGEW CHEM INT EDIT, V41, P814, DOI 10.1002/1521-3773(20020301)41:5<814::AID-ANIE814>3.0.CO

[4]

2-2

[5] The Calgary Biofilm Device: New technology for rapid determination of antibiotic susceptibilities of bacterial biofilms [J].

Ceri, H ;

Olson, ME ;

Stremick, C ;

Read, RR ;

Morck, D ;

Buret, A .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (06) :1771-1776

[6] Light-induced biocidal action of conjugated polyelectrolytes supported on colloids [J].

Chemburu, Sireesha ;

Corbitt, Thomas S. ;

Ista, Linnea K. ;

Ji, Eunkyung ;

Fulghum, Julia ;

Lopez, Gabriel P. ;

Ogawa, Katsu ;

Schanze, Kirk S. ;

Whitten, David G. .

LANGMUIR, 2008, 24 (19) :11053-11062

[7] MECHANISM OF ELECTRICAL ENHANCEMENT OF EFFICACY OF ANTIBIOTICS IN KILLING BIOFILM BACTERIA [J].

COSTERTON, JW ;

ELLIS, B ;

LAM, K ;

JOHNSON, F ;

KHOURY, AE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (12) :2803-2809

[8] Synthesis and antimicrobial activities of new water-soluble bis-quaternary ammonium methacrylate polymers [J].

Dizman, B ;

Elasri, MO ;

Mathias, LJ .

JOURNAL OF APPLIED POLYMER SCIENCE, 2004, 94 (02) :635-642

[9] Biofilms: Microbial life on surfaces [J].

Donlan, RM .

EMERGING INFECTIOUS DISEASES, 2002, 8 (09) :881-890

[10] Fabrication of Microbial Biofilm Arrays by Geometric Control of Cell Adhesion [J].

Eun, Ye-Jin ;

Weibel, Douglas B. .

LANGMUIR, 2009, 25 (08) :4643-4654

← 1 2 3 →