Enantioselective organocatalytic reactions of 4-hydroxycoumarin and 4-hydroxypyrone with α,β-unsaturated aldehydes -: An efficient Michael addition-acetalization cascade to chromenones, quinolinones and pyranones

被引：84
作者：
Rueping, Magnus [1 ]
Merino, Estibaliz [1 ]
Sugiono, Erli [1 ]
机构：
[1] Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60438 Frankfurt, Germany
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 13期
关键词：
bronsted acids; diarylprolinol ethers; domino reaction; iminium catalysis; pyranocoumarins;
D O I：
10.1002/adsc.200800340
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient, organocatalytic enantioselective addition-cyclization reaction of cyclic 1,3-dicarbonyl compounds with different alpha,beta-unsaturated aldehydes has been developed. The diarylprolinol ether-catalyzed reaction cascade provides a variety of chromenones, quinolinones and pyranones in good yields and with excellent enantioselectivities.
引用
收藏
页码：2127 / 2131
页数：5
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