HCV reinfection incidence and spontaneous clearance rates in HIV-positive men who have sex with men in Western Europe

被引:133
作者
Ingiliz, Patrick [1 ]
Martin, Thomas C. [2 ]
Rodger, Alison [3 ]
Stellbrink, Hans-Juergen [4 ]
Mauss, Stefan [5 ]
Boesecke, Christoph [6 ]
Mandorfer, Mattias [7 ]
Bottero, Julie [8 ]
Baumgarten, Axel [1 ]
Bhagani, Sanjay [3 ]
Lacombe, Karine [8 ,9 ]
Nelson, Mark [2 ,10 ]
Rockstroh, Juergen K.
机构
[1] Ctr Infectiol CIB, Seestr 13, Berlin, Germany
[2] Chelsea & Westminster Hosp, London, England
[3] Royal Free Hosp, London, England
[4] ICH, Hamburg, Germany
[5] Ctr HIV & Hepatogastroenterol, Dusseldorf, Germany
[6] Univ Bonn, Dept Med 1, Bonn, Germany
[7] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Vienna, Austria
[8] Hop St Antoine, AP HP, Serv Malad Infect & Trop, Paris, France
[9] UPMC Univ Paris 06, Sorbonne Univ, INSERM, IPLESP,UMRS 1136, Paris, France
[10] Imperial Coll Sch Med, London, England
关键词
HCV reinfection; Acute hepatitis C; HIV-HCV coinfection; SVR; Spontaneous clearance; HCV therapy; HEPATITIS-C VIRUS; SEXUALLY-TRANSMITTED INFECTION; DRUG-USERS; PEOPLE; EPIDEMIC; RISK; MSM; COLLABORATION; METAANALYSIS; PERSISTENCE;
D O I
10.1016/j.jhep.2016.09.004
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Moderate cure rates of acute hepatitis C virus (HCV) infections with pegylated interferon and ribavirin have been described in the last decade in men who have sex with men (MSM), who are also coinfected with the human immunodeficiency virus (HIV). However, a subsequent high incidence of HCV reinfections has been reported regionally in men who both clear the infection spontaneously or who respond to treatment. Methods: Retrospective analysis of reinfections in HIV infected MSM in eight centers from Austria, France, Germany, and the UK within the NEAT network between May 2002 and June 2014. Results: Of 606 individuals who cleared HCV spontaneously or were successfully treated, 149 (24.6%) presented with a subsequent HCV reinfection. Thirty out of 70 (43%) who cleared again or were successfully treated, presented with a second reinfection, 5 with a third, and one with a fourth reinfection. The reinfection incidence was 7.3/100 person-years (95% CI 6.2-8.6). We found a trend for lower incidence among individuals who had spontaneously cleared their incident infection than among individuals who were treated (Hazard ratio 0.62, 95% CI 0.38-1.02, p = 0.06). Spontaneous clearance of reinfection was associated with ALT levels >1000 IU/ml and spontaneous clearance of a prior infection. Conclusions: HCV reinfection is an issue of major concern in HIV positive MSM. Prevention strategies are needed for high risk groups to reduce morbidity and treatment costs. HIV-positive MSM with a prior HCV infection should be tested every 3 to 6 months for reinfection. Those who had achieved a reinfection should be tested every 3 months. Lay summary: We evaluated the occurrence of HCV reinfection in HIV-positive men who have sex with men. We found an alarming incidence of 7.3/100 person-years. Prevention measures need to address this specific subgroup of patients at high risk for HCV. (C) 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:282 / 287
页数:6
相关论文
共 40 条
[1]   Next-Generation Sequencing Sheds Light on the Natural History of Hepatitis C Infection in Patients Who Fail Treatment [J].
Abdelrahman, Tamer ;
Hughes, Joseph ;
Main, Janice ;
McLauchlan, John ;
Thursz, Mark ;
Thomson, Emma .
HEPATOLOGY, 2015, 61 (01) :88-97
[2]   Treatment of Hepatitis C Virus Infection Among People Who Are Actively Injecting Drugs: A Systematic Review and Meta-analysis [J].
Aspinall, Esther J. ;
Corson, Stephen ;
Doyle, Joseph S. ;
Grebely, Jason ;
Hutchinson, Sharon J. ;
Dore, Gregory J. ;
Goldberg, David J. ;
Hellard, Margaret E. .
CLINICAL INFECTIOUS DISEASES, 2013, 57 :S80-S89
[3]   Dual treatment of acute HCV infection in HIV co-infection: influence of HCV genotype upon treatment outcome [J].
Boesecke, Christoph ;
Ingiliz, Patrick ;
Reiberger, Thomas ;
Stellbrink, Hans-Juergen ;
Bhagani, Sanjay ;
Page, Emma ;
Mauss, Stefan ;
Lutz, Thomas ;
Voigt, Esther ;
Guiguet, Marguerite ;
Valantin, Marc-Antoine ;
Baumgarten, Axel ;
Nelson, Mark ;
Vogel, Martin ;
Rockstroh, Jurgen K. .
INFECTION, 2016, 44 (01) :93-101
[4]   Hepatitis C seroconversions in HIV infection across Europe: which regions and patient groups are affected? [J].
Boesecke, Christoph ;
Grint, Daniel ;
Soriano, Vincent ;
Lundgren, Jens D. ;
Monforte, Antonella d'Arminio ;
Mitsura, Victor M. ;
Chentsova, Nelly ;
Hadziosmanovic, Vesnadarjan ;
Kirk, Ole ;
Mocroft, Amanda ;
Peters, Lars ;
Rockstroh, Juergen K. .
LIVER INTERNATIONAL, 2015, 35 (11) :2384-2391
[5]   Treatment of acute hepatitis C infection in HIV-infected patients [J].
Boesecke, Christoph ;
Rockstroh, Juergen K. .
CURRENT OPINION IN HIV AND AIDS, 2011, 6 (04) :278-284
[6]   Illicit drug use in sexual settings ('chemsex') and HIV/STI transmission risk behaviour among gay men in South London: findings from a qualitative study [J].
Bourne, A. ;
Reid, D. ;
Hickson, F. ;
Torres-Rueda, S. ;
Weatherburn, P. .
SEXUALLY TRANSMITTED INFECTIONS, 2015, 91 (08) :564-568
[7]   Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours [J].
Danta, Mark ;
Brown, David ;
Bhagani, Sanjay ;
Pybus, Oliver G. ;
Sabin, Caroline A. ;
Nelson, Mark ;
Fisher, Martin ;
Johnson, Anne M. ;
Dusheiko, Geoffrey M. .
AIDS, 2007, 21 (08) :983-991
[8]   Recreational drug use, polydrug use, and sexual behaviour in HIV-diagnosed men who have sex with men in the UK: results from the cross-sectional ASTRA study [J].
Daskalopoulou, Marina ;
Rodger, Alison ;
Phillips, Andrew N. ;
Sherr, Lorraine ;
Speakman, Andrew ;
Collins, Simon ;
Elford, Jonathan ;
Johnson, Margaret A. ;
Gilson, Richard ;
Fisher, Martin ;
Wilkins, Ed ;
Anderson, Jane ;
McDonnell, Jeffrey ;
Edwards, Simon ;
Perry, Nicky ;
O'Connell, Rebecca ;
Lascar, Monica ;
Jones, Martin ;
Johnson, Anne M. ;
Hart, Graham ;
Miners, Alec ;
Geretti, Anna-Maria ;
Burman, William J. ;
Lampe, Fiona C. .
LANCET HIV, 2014, 1 (01) :E22-E31
[9]   The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies [J].
Farci, P ;
Shimoda, A ;
Coiana, A ;
Diaz, G ;
Peddis, G ;
Melpolder, JC ;
Strazzera, A ;
Chien, DY ;
Munoz, SJ ;
Balestrieri, A ;
Purcell, RH ;
Alter, HJ .
SCIENCE, 2000, 288 (5464) :339-344
[10]   Hepatitis C Virus Reinfection Following Treatment Among People Who Use Drugs [J].
Grady, Bart P. ;
Schinkel, Janke ;
Thomas, Xiomara V. ;
Dalgard, Olav .
CLINICAL INFECTIOUS DISEASES, 2013, 57 :S105-S110